How RNA acts as a nuclease: some mechanistic comparisons in the nucleolytic ribozymes

David M. J. Lilley (Lead / Corresponding author)

Research output: Contribution to journalReview article

13 Citations (Scopus)
639 Downloads (Pure)

Abstract

Recent structural and mechanistic studies have shed considerable light on the catalytic mechanisms of nucleolytic ribozymes. The discovery of several new ribozymes in this class has now allowed comparisons to be made, and the beginnings of mechanistic groupings to emerge.

Original languageEnglish
Pages (from-to)683-691
Number of pages9
JournalBiochemical Society Transactions
Volume45
Issue number3
DOIs
Publication statusPublished - 15 Jun 2017

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Catalytic RNA
RNA

Keywords

  • HDV
  • Hepatitis delta virus
  • Quantum mechanical/molecular mechanical
  • Varkud satellite

Cite this

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title = "How RNA acts as a nuclease: some mechanistic comparisons in the nucleolytic ribozymes",
abstract = "Recent structural and mechanistic studies have shed considerable light on the catalytic mechanisms of nucleolytic ribozymes. The discovery of several new ribozymes in this class has now allowed comparisons to be made, and the beginnings of mechanistic groupings to emerge.",
keywords = "HDV, Hepatitis delta virus, Quantum mechanical/molecular mechanical, Varkud satellite",
author = "Lilley, {David M. J.}",
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AB - Recent structural and mechanistic studies have shed considerable light on the catalytic mechanisms of nucleolytic ribozymes. The discovery of several new ribozymes in this class has now allowed comparisons to be made, and the beginnings of mechanistic groupings to emerge.

KW - HDV

KW - Hepatitis delta virus

KW - Quantum mechanical/molecular mechanical

KW - Varkud satellite

U2 - 10.1042/BST20160158

DO - 10.1042/BST20160158

M3 - Review article

C2 - 28620029

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JO - Biochemical Society Transactions

JF - Biochemical Society Transactions

SN - 0300-5127

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