How RNA acts as a nuclease: some mechanistic comparisons in the nucleolytic ribozymes

David M. J. Lilley

doi:10.1042/BST20160158

How RNA acts as a nuclease: some mechanistic comparisons in the nucleolytic ribozymes

David M. J. Lilley (Lead / Corresponding author)

Research output: Contribution to journal › Review article › peer-review

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Abstract

Recent structural and mechanistic studies have shed considerable light on the catalytic mechanisms of nucleolytic ribozymes. The discovery of several new ribozymes in this class has now allowed comparisons to be made, and the beginnings of mechanistic groupings to emerge.

Original language	English
Pages (from-to)	683-691
Number of pages	9
Journal	Biochemical Society Transactions
Volume	45
Issue number	3
DOIs	https://doi.org/10.1042/BST20160158
Publication status	Published - 15 Jun 2017

Keywords

HDV
Hepatitis delta virus
Quantum mechanical/molecular mechanical
Varkud satellite

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1042/BST20160158

Author Accepted ManuscriptAccepted author manuscript, 148 KB

Dynamics of Eukaryotic Junction-Resolving Enzyme GEN1 - DNA Junction Interactions
Lilley, D. (Investigator)
Biotechnology and Biological Sciences Research Council
1/10/16 → 30/09/19
Project: Research
Fluorescence Resonance Energy Transfer as a Rich Source of Orientational Information in Nucleic Acid Structure
Lilley, D. (Investigator)
Engineering and Physical Sciences Research Council
1/09/12 → 30/06/16
Project: Research

Cite this

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title = "How RNA acts as a nuclease: some mechanistic comparisons in the nucleolytic ribozymes",

abstract = "Recent structural and mechanistic studies have shed considerable light on the catalytic mechanisms of nucleolytic ribozymes. The discovery of several new ribozymes in this class has now allowed comparisons to be made, and the beginnings of mechanistic groupings to emerge.",

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AB - Recent structural and mechanistic studies have shed considerable light on the catalytic mechanisms of nucleolytic ribozymes. The discovery of several new ribozymes in this class has now allowed comparisons to be made, and the beginnings of mechanistic groupings to emerge.

KW - HDV

KW - Hepatitis delta virus

KW - Quantum mechanical/molecular mechanical

KW - Varkud satellite

U2 - 10.1042/BST20160158

DO - 10.1042/BST20160158

M3 - Review article

C2 - 28620029

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VL - 45

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JO - Biochemical Society Transactions

JF - Biochemical Society Transactions

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How RNA acts as a nuclease: some mechanistic comparisons in the nucleolytic ribozymes

Abstract

Keywords

UN SDGs

Access to Document

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Projects

Dynamics of Eukaryotic Junction-Resolving Enzyme GEN1 - DNA Junction Interactions

Fluorescence Resonance Energy Transfer as a Rich Source of Orientational Information in Nucleic Acid Structure

Cite this