How to be a mitotic chromosome

Sandra C. Moser, Jason R. Swedlow

    Research output: Contribution to journalArticlepeer-review

    19 Citations (Scopus)

    Abstract

    Proper mitotic chromosome structure is essential for faithful chromosome segregation. Mounting evidence suggests that mitotic chromosome assembly is a progressive, dynamic process that requires topoisomerase II, condensins and cohesin and the activity of several signalling molecules. Current results suggest how these different activities might interact to achieve the familiar form of the mitotic chromosome.

    Original languageEnglish
    Pages (from-to)307-319
    Number of pages13
    JournalChromosome Research
    Volume19
    Issue number3
    DOIs
    Publication statusPublished - Apr 2011

    Keywords

    • chromosome structure
    • condensation
    • condensin
    • topoisomerase II
    • cohesin
    • DNA TOPOISOMERASE-II
    • SISTER-CHROMATID RESOLUTION
    • HISTONE H3 PHOSPHORYLATION
    • CELL-CYCLE PROGRESSION
    • CONDENSATION IN-VITRO
    • AURORA-B KINASE
    • METAPHASE CHROMOSOME
    • SACCHAROMYCES-CEREVISIAE
    • FISSION YEAST
    • COHESIN REMOVAL

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