Howdo Cdc7 and cyclin-dependent kinases trigger the initiation of chromosome replication in eukaryotic cells?

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    Abstract

    Chromosome replication occurs precisely once during the cell cycle of almost all eukaryotic cells, and is a highly complex process that is still understood relatively poorly. Two conserved kinases called Cdc7 (cell division cycle 7) and cyclin-dependent kinase (CDK) are required to establish replication forks during the initiation of chromosome replication, and a key feature of this process is the activation of the replicative DNA helicase in situ at each origin of DNA replication. A series of recent studies has shed new light on the targets of Cdc7 and CDK, indicating that chromosome replication probably initiates by a fundamentally similar mechanism in all eukaryotes.
    Original languageEnglish
    Pages (from-to)1208-1219
    Number of pages12
    JournalGenes & Development
    Volume24
    Issue number12
    DOIs
    Publication statusPublished - 15 Jun 2010

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