Howdo Cdc7 and cyclin-dependent kinases trigger the initiation of chromosome replication in eukaryotic cells?

TY - JOUR

T1 - Howdo Cdc7 and cyclin-dependent kinases trigger the initiation of chromosome replication in eukaryotic cells?

AU - Labib, Karim

PY - 2010/6/15

Y1 - 2010/6/15

N2 - Chromosome replication occurs precisely once during the cell cycle of almost all eukaryotic cells, and is a highly complex process that is still understood relatively poorly. Two conserved kinases called Cdc7 (cell division cycle 7) and cyclin-dependent kinase (CDK) are required to establish replication forks during the initiation of chromosome replication, and a key feature of this process is the activation of the replicative DNA helicase in situ at each origin of DNA replication. A series of recent studies has shed new light on the targets of Cdc7 and CDK, indicating that chromosome replication probably initiates by a fundamentally similar mechanism in all eukaryotes.

AB - Chromosome replication occurs precisely once during the cell cycle of almost all eukaryotic cells, and is a highly complex process that is still understood relatively poorly. Two conserved kinases called Cdc7 (cell division cycle 7) and cyclin-dependent kinase (CDK) are required to establish replication forks during the initiation of chromosome replication, and a key feature of this process is the activation of the replicative DNA helicase in situ at each origin of DNA replication. A series of recent studies has shed new light on the targets of Cdc7 and CDK, indicating that chromosome replication probably initiates by a fundamentally similar mechanism in all eukaryotes.

UR - https://www.scopus.com/pages/publications/77953954908

U2 - 10.1101/gad.1933010

DO - 10.1101/gad.1933010

M3 - Article

C2 - 20551170

AN - SCOPUS:77953954908

SN - 0890-9369

VL - 24

SP - 1208

EP - 1219

JO - Genes & Development

JF - Genes & Development

IS - 12

ER -