Human papillomavirus variants and squamous neoplasia of the cervix

Athina Giannoudis; C. Simon  Herrington

doi:10.1002/1096-9896(2000)9999:9999<::AID-PATH809>3.0.CO;2-C

Human papillomavirus variants and squamous neoplasia of the cervix

Athina Giannoudis
, C. Simon Herrington

Research output: Contribution to journal › Review article › peer-review

101 Citations (Scopus)

Abstract

Human papillomaviruses (HPVs) play a central role in the aetiology of cervical neoplasia, However, only a small proportion of cervical intraepithelial lesions infected with high-risk HPVs will progress to invasive cervical carcinoma, which indicates the involvement of additional factors, An important emerging viral factor is naturally occurring intratypic sequence variation, Such variation has been used to study the geographical spread of HPVs, but there is increasing evidence that it may be important in determining the risk of development of neoplastic disease. The collected data indicate that different HPV variants have altered biochemical and biological properties and represent an additional risk factor in the development of squamous intraepithelial lesions and invasive carcinoma of the cervix. This may be relevant not only to the biology of HPV infection and its association with squamous neoplasia, but also to the use of HPV typing in clinical practice, Copyright (C) 2000 John Wiley & Sons, Ltd.

Original language	English
Pages (from-to)	295-302
Number of pages	8
Journal	Journal of Pathology
Volume	193
Issue number	3
Early online date	22 Dec 2000
DOIs	https://doi.org/10.1002/1096-9896(2000)9999:9999<::AID-PATH809>3.0.CO;2-C
Publication status	Published - Mar 2001

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Papillomavirus
Variant
Cervix
Neoplasia

Access to Document

10.1002/1096-9896(2000)9999:9999<::AID-PATH809>3.0.CO;2-C

Cite this

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title = "Human papillomavirus variants and squamous neoplasia of the cervix",

abstract = "Human papillomaviruses (HPVs) play a central role in the aetiology of cervical neoplasia, However, only a small proportion of cervical intraepithelial lesions infected with high-risk HPVs will progress to invasive cervical carcinoma, which indicates the involvement of additional factors, An important emerging viral factor is naturally occurring intratypic sequence variation, Such variation has been used to study the geographical spread of HPVs, but there is increasing evidence that it may be important in determining the risk of development of neoplastic disease. The collected data indicate that different HPV variants have altered biochemical and biological properties and represent an additional risk factor in the development of squamous intraepithelial lesions and invasive carcinoma of the cervix. This may be relevant not only to the biology of HPV infection and its association with squamous neoplasia, but also to the use of HPV typing in clinical practice, Copyright (C) 2000 John Wiley \& Sons, Ltd.",

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AU - Herrington, C. Simon

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AB - Human papillomaviruses (HPVs) play a central role in the aetiology of cervical neoplasia, However, only a small proportion of cervical intraepithelial lesions infected with high-risk HPVs will progress to invasive cervical carcinoma, which indicates the involvement of additional factors, An important emerging viral factor is naturally occurring intratypic sequence variation, Such variation has been used to study the geographical spread of HPVs, but there is increasing evidence that it may be important in determining the risk of development of neoplastic disease. The collected data indicate that different HPV variants have altered biochemical and biological properties and represent an additional risk factor in the development of squamous intraepithelial lesions and invasive carcinoma of the cervix. This may be relevant not only to the biology of HPV infection and its association with squamous neoplasia, but also to the use of HPV typing in clinical practice, Copyright (C) 2000 John Wiley & Sons, Ltd.

KW - Papillomavirus

KW - Variant

KW - Cervix

KW - Neoplasia

U2 - 10.1002/1096-9896(2000)9999:9999<::AID-PATH809>3.0.CO;2-C

DO - 10.1002/1096-9896(2000)9999:9999<::AID-PATH809>3.0.CO;2-C

M3 - Review article

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Human papillomavirus variants and squamous neoplasia of the cervix

Abstract

UN SDGs

Keywords

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