Human papillomaviruses, tumour suppressor genes and cervical cancer

G. J. Inman, I. D. Cook, R K Lau

    Research output: Contribution to journalArticle

    11 Citations (Scopus)

    Abstract

    There is now a considerable body of evidence that links HPV infection with anogenital squamous carcinoma, particularly for specific 'high risk' HPV types (HPV16 and 18) and invasive carcinoma of the cervix. Recent advances in the molecular study of these viruses have elucidated some potential mechanisms by which they may contribute to the development of these diseases. In this review we concentrate on the interactions of 2 of the HPV encoded proteins, E6 and E7, with cellular tumour suppressor gene products. We provide a model of how these interactions may be important in tumourigenesis and draw together current knowledge of this exciting and rapidly evolving field.
    Original languageEnglish
    Pages (from-to)128-134
    Number of pages7
    JournalInternational journal of STD & AIDS
    Volume4
    Issue number3
    Publication statusPublished - 1993

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