Human papillomaviruses, tumour suppressor genes and cervical cancer

G. J. Inman, I. D. Cook, R K Lau

    Research output: Contribution to journalArticle

    11 Citations (Scopus)

    Abstract

    There is now a considerable body of evidence that links HPV infection with anogenital squamous carcinoma, particularly for specific 'high risk' HPV types (HPV16 and 18) and invasive carcinoma of the cervix. Recent advances in the molecular study of these viruses have elucidated some potential mechanisms by which they may contribute to the development of these diseases. In this review we concentrate on the interactions of 2 of the HPV encoded proteins, E6 and E7, with cellular tumour suppressor gene products. We provide a model of how these interactions may be important in tumourigenesis and draw together current knowledge of this exciting and rapidly evolving field.
    Original languageEnglish
    Pages (from-to)128-134
    Number of pages7
    JournalInternational journal of STD & AIDS
    Volume4
    Issue number3
    Publication statusPublished - 1993

    Fingerprint

    Human papillomavirus 18
    Tumor Suppressor Genes
    Cervix Uteri
    Uterine Cervical Neoplasms
    Squamous Cell Carcinoma
    Viruses
    Carcinoma
    Infection
    Proteins

    Cite this

    @article{25c0979a0e9c4a36968bbbc3ae48ee8e,
    title = "Human papillomaviruses, tumour suppressor genes and cervical cancer",
    abstract = "There is now a considerable body of evidence that links HPV infection with anogenital squamous carcinoma, particularly for specific 'high risk' HPV types (HPV16 and 18) and invasive carcinoma of the cervix. Recent advances in the molecular study of these viruses have elucidated some potential mechanisms by which they may contribute to the development of these diseases. In this review we concentrate on the interactions of 2 of the HPV encoded proteins, E6 and E7, with cellular tumour suppressor gene products. We provide a model of how these interactions may be important in tumourigenesis and draw together current knowledge of this exciting and rapidly evolving field.",
    author = "Inman, {G. J.} and Cook, {I. D.} and Lau, {R K}",
    year = "1993",
    language = "English",
    volume = "4",
    pages = "128--134",
    journal = "International journal of STD & AIDS",
    issn = "0956-4624",
    publisher = "SAGE Publications",
    number = "3",

    }

    Human papillomaviruses, tumour suppressor genes and cervical cancer. / Inman, G. J.; Cook, I. D.; Lau, R K.

    In: International journal of STD & AIDS, Vol. 4, No. 3, 1993, p. 128-134.

    Research output: Contribution to journalArticle

    TY - JOUR

    T1 - Human papillomaviruses, tumour suppressor genes and cervical cancer

    AU - Inman, G. J.

    AU - Cook, I. D.

    AU - Lau, R K

    PY - 1993

    Y1 - 1993

    N2 - There is now a considerable body of evidence that links HPV infection with anogenital squamous carcinoma, particularly for specific 'high risk' HPV types (HPV16 and 18) and invasive carcinoma of the cervix. Recent advances in the molecular study of these viruses have elucidated some potential mechanisms by which they may contribute to the development of these diseases. In this review we concentrate on the interactions of 2 of the HPV encoded proteins, E6 and E7, with cellular tumour suppressor gene products. We provide a model of how these interactions may be important in tumourigenesis and draw together current knowledge of this exciting and rapidly evolving field.

    AB - There is now a considerable body of evidence that links HPV infection with anogenital squamous carcinoma, particularly for specific 'high risk' HPV types (HPV16 and 18) and invasive carcinoma of the cervix. Recent advances in the molecular study of these viruses have elucidated some potential mechanisms by which they may contribute to the development of these diseases. In this review we concentrate on the interactions of 2 of the HPV encoded proteins, E6 and E7, with cellular tumour suppressor gene products. We provide a model of how these interactions may be important in tumourigenesis and draw together current knowledge of this exciting and rapidly evolving field.

    M3 - Article

    VL - 4

    SP - 128

    EP - 134

    JO - International journal of STD & AIDS

    JF - International journal of STD & AIDS

    SN - 0956-4624

    IS - 3

    ER -