Projects per year
Abstract
Purpose: The purpose of this investigation was to evaluate human Thiel-embalmed cadavers with the addition of extracorporeal driven ante-grade pulsatile flow in the aorta as a model for simulation training in interventional techniques and endovascular device testing.
Materials and Methods: Three human cadavers embalmed according to the method of Thiel were selected. Extracorporeal pulsatile ante-grade flow of 2.5 L per min was delivered directly into the aorta of the cadavers via a surgically placed connection. During perfusion, aortic pressure and temperature were recorded and optimized for physiologically similar parameters. Pre- and post-procedure CT imaging was conducted to plan and follow up thoracic and abdominal endovascular aortic repair as it would be in a clinical scenario. Thoracic endovascular aortic repair (TEVAR) and endovascular abdominal repair (EVAR) procedures were conducted in simulation of a clinical case, under fluoroscopic guidance with a multidisciplinary team present.
Results: The Thiel cadaveric aortic perfusion model provided pulsatile ante-grade flow, with pressure and temperature, sufficient to conduct a realistic simulation of TEVAR and EVAR procedures. Fluoroscopic imaging provided guidance during the intervention. Pre- and post-procedure CT imaging facilitated planning and follow-up evaluation of the procedure.
Conclusion: The human Thiel-embalmed cadavers with the addition of extracorporeal flow within the aorta offer an anatomically appropriate, physiologically similar robust model to simulate aortic endovascular procedures, with potential applications in interventional radiology training and medical device testing as a pre-clinical model.
Materials and Methods: Three human cadavers embalmed according to the method of Thiel were selected. Extracorporeal pulsatile ante-grade flow of 2.5 L per min was delivered directly into the aorta of the cadavers via a surgically placed connection. During perfusion, aortic pressure and temperature were recorded and optimized for physiologically similar parameters. Pre- and post-procedure CT imaging was conducted to plan and follow up thoracic and abdominal endovascular aortic repair as it would be in a clinical scenario. Thoracic endovascular aortic repair (TEVAR) and endovascular abdominal repair (EVAR) procedures were conducted in simulation of a clinical case, under fluoroscopic guidance with a multidisciplinary team present.
Results: The Thiel cadaveric aortic perfusion model provided pulsatile ante-grade flow, with pressure and temperature, sufficient to conduct a realistic simulation of TEVAR and EVAR procedures. Fluoroscopic imaging provided guidance during the intervention. Pre- and post-procedure CT imaging facilitated planning and follow-up evaluation of the procedure.
Conclusion: The human Thiel-embalmed cadavers with the addition of extracorporeal flow within the aorta offer an anatomically appropriate, physiologically similar robust model to simulate aortic endovascular procedures, with potential applications in interventional radiology training and medical device testing as a pre-clinical model.
Original language | English |
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Pages (from-to) | 1454-1460 |
Number of pages | 7 |
Journal | Cardiovascular and Interventional Radiology |
Volume | 40 |
Issue number | 9 |
Early online date | 27 Apr 2017 |
DOIs | |
Publication status | Published - 30 Apr 2017 |
Keywords
- Cadaveric perfusion
- Endovascular training
- Endovascular aortic aneurysm repair (EVAR)
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Dive into the research topics of 'Human Thiel-Embalmed Cadaveric Aortic Model with Perfusion for Endovascular Intervention Training and Medical Device Evaluation'. Together they form a unique fingerprint.Projects
- 1 Finished
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ReDVA: Development of Hemodynamic Solutions in Renal Dialysis Venous Access Failure (Joint with Guerbet SA, University of Limerick, Vascular Flow Technologies Ltd and University Hospital Birmingham NHS Foundation Trust)
Chakraverty, S. (Investigator), Corner, G. (Investigator), Houston, G. (Investigator), Melzer, A. (Investigator), Stonebridge, P. (Investigator) & Suttie, S. (Investigator)
COMMISSION OF THE EUROPEAN COMMUNITIES
1/10/13 → 30/09/17
Project: Research
Profiles
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Melzer, Andreas
- Neuroscience - Professor and Director of IMSAT (Teaching and Research)
Person: Academic