Hyaluronic acid binding ability of human sperm reflects cellular maturity and fertilizing potential: Selection of sperm for intracytoplasmic sperm injection

Gabor Huszar; Sinan Ozkavukcu; Attila Jakab; Ciler Celik-Ozenci; G. Leyla Sati; Sevil Cayli

doi:10.1097/01.gco.0000193018.98061.2f

Hyaluronic acid binding ability of human sperm reflects cellular maturity and fertilizing potential: Selection of sperm for intracytoplasmic sperm injection

Gabor Huszar (Lead / Corresponding author)
, Sinan Ozkavukcu
, Attila Jakab
, Ciler Celik-Ozenci
, G. Leyla Sati
, Sevil Cayli

Postgraduate Medicine

Research output: Contribution to journal › Review article › peer-review

119 Citations (Scopus)

Abstract

Purpose of review

The current concepts of sperm biochemical markers and the central role of the HspA2 chaperone protein, a measure of sperm cellular maturity and fertilizing potential, are reviewed.

Recent findings

Because HspA2 is a component of the synaptonemal complex, low HspA2 levels and increased frequency of chromosomal aneuploidies are related in diminished maturity sperm. We also suggest a relationship between HspA2 expression in elongating spermatids and events of late spermiogenesis, such as cytoplasmic extrusion and plasma membrane remodeling that aid the formation of the zona pellucida binding and hyaluronic acid binding sites. The presence of hyaluronic acid receptor on the plasma membrane of mature sperm, coupled with hyaluronic acid coated glass or plastic surfaces, facilitates testing of sperm function and selection of single mature sperm for intracytoplasmic sperm injection. The frequencies of sperm with chromosomal disomy are reduced approximately fourfold to fivefold in hyaluronic acid selected sperm compared with semen sperm, comparable to the increase in such abnormalities in intracytoplasmic sperm injection offspring. Hyaluronic acid binding also excludes immature sperm with cytoplasmic extrusion, persistent histones, and DNA chain breaks.

Summary

Hyaluronic acid mediated sperm selection is a novel technique that is comparable to sperm zona pellucida binding. Hyaluronic acid selected sperm will also alleviate the risks related to intracytoplasmic sperm injection fertilization with sperm of diminished maturity that currently cause worldwide concern.

Original language	English
Pages (from-to)	260-267
Number of pages	8
Journal	Current Opinion in Obstetrics and Gynecology
Volume	18
Issue number	3
DOIs	https://doi.org/10.1097/01.gco.0000193018.98061.2f
Publication status	Published - Jun 2006

Keywords

Chromosomal disomy and diploidy
Intracytoplasmic sperm injection
Sperm maturation
Zona pellucida binding

ASJC Scopus subject areas

Obstetrics and Gynaecology

Access to Document

10.1097/01.gco.0000193018.98061.2f

Cite this

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title = "Hyaluronic acid binding ability of human sperm reflects cellular maturity and fertilizing potential: Selection of sperm for intracytoplasmic sperm injection",

abstract = "Purpose of reviewThe current concepts of sperm biochemical markers and the central role of the HspA2 chaperone protein, a measure of sperm cellular maturity and fertilizing potential, are reviewed. Recent findingsBecause HspA2 is a component of the synaptonemal complex, low HspA2 levels and increased frequency of chromosomal aneuploidies are related in diminished maturity sperm. We also suggest a relationship between HspA2 expression in elongating spermatids and events of late spermiogenesis, such as cytoplasmic extrusion and plasma membrane remodeling that aid the formation of the zona pellucida binding and hyaluronic acid binding sites. The presence of hyaluronic acid receptor on the plasma membrane of mature sperm, coupled with hyaluronic acid coated glass or plastic surfaces, facilitates testing of sperm function and selection of single mature sperm for intracytoplasmic sperm injection. The frequencies of sperm with chromosomal disomy are reduced approximately fourfold to fivefold in hyaluronic acid selected sperm compared with semen sperm, comparable to the increase in such abnormalities in intracytoplasmic sperm injection offspring. Hyaluronic acid binding also excludes immature sperm with cytoplasmic extrusion, persistent histones, and DNA chain breaks.SummaryHyaluronic acid mediated sperm selection is a novel technique that is comparable to sperm zona pellucida binding. Hyaluronic acid selected sperm will also alleviate the risks related to intracytoplasmic sperm injection fertilization with sperm of diminished maturity that currently cause worldwide concern.",

keywords = "Chromosomal disomy and diploidy, Intracytoplasmic sperm injection, Sperm maturation, Zona pellucida binding",

author = "Gabor Huszar and Sinan Ozkavukcu and Attila Jakab and Ciler Celik-Ozenci and Sati, \{G. Leyla\} and Sevil Cayli",

year = "2006",

month = jun,

doi = "10.1097/01.gco.0000193018.98061.2f",

language = "English",

volume = "18",

pages = "260--267",

journal = "Current Opinion in Obstetrics and Gynecology",

issn = "1040-872X",

publisher = "Lippincott Williams and Wilkins",

number = "3",

}

Hyaluronic acid binding ability of human sperm reflects cellular maturity and fertilizing potential: Selection of sperm for intracytoplasmic sperm injection. / Huszar, Gabor (Lead / Corresponding author); Ozkavukcu, Sinan; Jakab, Attila et al.
In: Current Opinion in Obstetrics and Gynecology, Vol. 18, No. 3, 06.2006, p. 260-267.

Research output: Contribution to journal › Review article › peer-review

TY - JOUR

T1 - Hyaluronic acid binding ability of human sperm reflects cellular maturity and fertilizing potential

T2 - Selection of sperm for intracytoplasmic sperm injection

AU - Huszar, Gabor

AU - Ozkavukcu, Sinan

AU - Jakab, Attila

AU - Celik-Ozenci, Ciler

AU - Sati, G. Leyla

AU - Cayli, Sevil

PY - 2006/6

Y1 - 2006/6

N2 - Purpose of reviewThe current concepts of sperm biochemical markers and the central role of the HspA2 chaperone protein, a measure of sperm cellular maturity and fertilizing potential, are reviewed. Recent findingsBecause HspA2 is a component of the synaptonemal complex, low HspA2 levels and increased frequency of chromosomal aneuploidies are related in diminished maturity sperm. We also suggest a relationship between HspA2 expression in elongating spermatids and events of late spermiogenesis, such as cytoplasmic extrusion and plasma membrane remodeling that aid the formation of the zona pellucida binding and hyaluronic acid binding sites. The presence of hyaluronic acid receptor on the plasma membrane of mature sperm, coupled with hyaluronic acid coated glass or plastic surfaces, facilitates testing of sperm function and selection of single mature sperm for intracytoplasmic sperm injection. The frequencies of sperm with chromosomal disomy are reduced approximately fourfold to fivefold in hyaluronic acid selected sperm compared with semen sperm, comparable to the increase in such abnormalities in intracytoplasmic sperm injection offspring. Hyaluronic acid binding also excludes immature sperm with cytoplasmic extrusion, persistent histones, and DNA chain breaks.SummaryHyaluronic acid mediated sperm selection is a novel technique that is comparable to sperm zona pellucida binding. Hyaluronic acid selected sperm will also alleviate the risks related to intracytoplasmic sperm injection fertilization with sperm of diminished maturity that currently cause worldwide concern.

AB - Purpose of reviewThe current concepts of sperm biochemical markers and the central role of the HspA2 chaperone protein, a measure of sperm cellular maturity and fertilizing potential, are reviewed. Recent findingsBecause HspA2 is a component of the synaptonemal complex, low HspA2 levels and increased frequency of chromosomal aneuploidies are related in diminished maturity sperm. We also suggest a relationship between HspA2 expression in elongating spermatids and events of late spermiogenesis, such as cytoplasmic extrusion and plasma membrane remodeling that aid the formation of the zona pellucida binding and hyaluronic acid binding sites. The presence of hyaluronic acid receptor on the plasma membrane of mature sperm, coupled with hyaluronic acid coated glass or plastic surfaces, facilitates testing of sperm function and selection of single mature sperm for intracytoplasmic sperm injection. The frequencies of sperm with chromosomal disomy are reduced approximately fourfold to fivefold in hyaluronic acid selected sperm compared with semen sperm, comparable to the increase in such abnormalities in intracytoplasmic sperm injection offspring. Hyaluronic acid binding also excludes immature sperm with cytoplasmic extrusion, persistent histones, and DNA chain breaks.SummaryHyaluronic acid mediated sperm selection is a novel technique that is comparable to sperm zona pellucida binding. Hyaluronic acid selected sperm will also alleviate the risks related to intracytoplasmic sperm injection fertilization with sperm of diminished maturity that currently cause worldwide concern.

KW - Chromosomal disomy and diploidy

KW - Intracytoplasmic sperm injection

KW - Sperm maturation

KW - Zona pellucida binding

UR - https://www.scopus.com/pages/publications/33744967944

U2 - 10.1097/01.gco.0000193018.98061.2f

DO - 10.1097/01.gco.0000193018.98061.2f

M3 - Review article

C2 - 16735824

AN - SCOPUS:33744967944

SN - 1040-872X

VL - 18

SP - 260

EP - 267

JO - Current Opinion in Obstetrics and Gynecology

JF - Current Opinion in Obstetrics and Gynecology

IS - 3

ER -

Hyaluronic acid binding ability of human sperm reflects cellular maturity and fertilizing potential: Selection of sperm for intracytoplasmic sperm injection

Abstract

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