Hydatidiform moles and mimics: an up-to-date review on morphology and immunocytochemistry to aid the diagnosis

TY - JOUR

T1 - Hydatidiform moles and mimics

T2 - an up-to-date review on morphology and immunocytochemistry to aid the diagnosis

AU - Christie, Lesley

AU - McMahon, Lesley M.

N1 - Publisher Copyright: © 2025 Published by Elsevier Ltd.

PY - 2026/1

Y1 - 2026/1

N2 - Sporadic miscarriages occur in 10–20% of all pregnancies and affect one in four women. Products of conception (POC) are one of the commonest specimens submitted to the histopathology laboratory. The pathologist's role is to adequately sample, confirm a pregnancy and identify or exclude a molar pregnancy. This review summarises the genetic basis of the disease, key diagnostic features and ancillary investigations that can be employed to classify a gestation. Accurate and timely diagnosis of molar pregnancy ensures appropriate follow up and favourable outcomes.

AB - Sporadic miscarriages occur in 10–20% of all pregnancies and affect one in four women. Products of conception (POC) are one of the commonest specimens submitted to the histopathology laboratory. The pathologist's role is to adequately sample, confirm a pregnancy and identify or exclude a molar pregnancy. This review summarises the genetic basis of the disease, key diagnostic features and ancillary investigations that can be employed to classify a gestation. Accurate and timely diagnosis of molar pregnancy ensures appropriate follow up and favourable outcomes.

KW - Chorionic villi

KW - genetics

KW - gestational trophoblastic disease

KW - molar pregnancy

KW - products of conception

UR - https://www.scopus.com/pages/publications/105025983262

U2 - 10.1016/j.mpdhp.2025.10.006

DO - 10.1016/j.mpdhp.2025.10.006

M3 - Review article

AN - SCOPUS:105025983262

SN - 1756-2317

VL - 32

SP - 12

EP - 25

JO - Diagnostic Histopathology

JF - Diagnostic Histopathology

IS - 1

ER -