Hydrodynamic stretching for prostate cancer detection

Yuri Belotti, Michael Conneely, Scott Palmer, Tianjun Huang, Paul Andrew Campbell, Stephen McKenna, Ghulam Nabi, David McGloin

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)


Advances in diagnostic technologies enabled scientists to link a large number of diseases with structural changes of the intracellular organisation. This intrinsic biophysical characteristic opened up the possibility to perform clinical assessments based on the measurement of single-cell mechanical properties. In this work, we combine microfluidics, high speed imaging and computational automatic tracking to measure the single-cell deformability of large samples of prostate cancer cells at a rate of ∼ 104cells/s. Such a high throughput accounts for the inherent heterogeneity of biological samples and enabled us to extract statistically meaningful signatures from each cell population. In addition, using our technique we investigate the effect of Latrunculin A to the cellular stiffness.

Original languageEnglish
Title of host publicationBio-MEMS and Medical Microdevices II
EditorsSander van den Driesche
Place of PublicationBellingham
PublisherSPIE-International Society for Optical Engineering
ISBN (Print)9781628416411
Publication statusPublished - 1 Jun 2015
EventSPIE Microtechnologies 2015: Bio-MEMS and Medical Microdevices II - Hotel Alimara, Barcelona, Spain
Duration: 4 May 20156 May 2015
http://spie.org/conferences-and-exhibitions/past-events/past-conferences-and-exhibitions/past-events/microtechnologies/microtechnologies-2015 (Link to conference)

Publication series

NameProceedings of SPIE


ConferenceSPIE Microtechnologies 2015: Bio-MEMS and Medical Microdevices II
Internet address


  • Automated Tracking
  • Cell Mechanics
  • High Speed Imaging
  • High Throughput Diagnosis
  • Microfluidics
  • Prostate Cancer

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics
  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Radiology Nuclear Medicine and imaging


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