TY - JOUR
T1 - Hypergonadotropic hypogonadism and chromosomal aberrations
T2 - clinical heterogeneity and implications on the health of elderly men, case series
AU - Elhadd, Tarik
AU - Majzoub, Ahmad
AU - Wilson, Charlotte
AU - McCreight, Laura
AU - Mohamed, Muna S.
AU - Green, Fiona C.
AU - Collier, Andrew J.
N1 - Funding Information:
Open Access funding provided by the Qatar National Library.
Copyright:
© 2023. The Author(s).
PY - 2023/5/17
Y1 - 2023/5/17
N2 - Background: Hypogonadism in older men is often considered as late onset hypogonadism. However, this clinical condition results from primary testicular failure which could be of genetic origin with Klinefelter syndrome being the most common chromosomal abnormality associated with it.Case Presentation: We report a heterogeneous group of cases who were diagnosed with hypergonadotropic hypogonadism in their adulthood and were found to have rare chromosomal aberrations. All were elderly men (in their 70 s and 80 s) for whom the diagnosis was made during the evaluation of incidental symptoms suggestive of endocrinopathy. The first had hyponatremia; the other two had gynaecomastia and features of hypogonadism noted during admission for various acute medical problems. With respect to their genetic results; the first had a male karyotype with balanced reciprocal translocation between the long arm of chromosome 4 and the short arm of chromosome 7. The second case had a male karotype with one normal X chromosome and an isochrome for the short arm of the Y chromosome. The third case was an XX male with unbalanced translocation between the X & Y chromosomes with retention of the SRY locus.Conclusion: Hypergonadotrophic hypogonadism in the elderly, may be due to chromosomal aberrations, resulting in heterogeneous and diverse clinical phenotypes. Vigilance must be exercised when seeing cases with subtle clinical findings. This report suggests that in selected cases of adult hypergonadotropic hypogonadism, chromosomal analysis may be indicated.
AB - Background: Hypogonadism in older men is often considered as late onset hypogonadism. However, this clinical condition results from primary testicular failure which could be of genetic origin with Klinefelter syndrome being the most common chromosomal abnormality associated with it.Case Presentation: We report a heterogeneous group of cases who were diagnosed with hypergonadotropic hypogonadism in their adulthood and were found to have rare chromosomal aberrations. All were elderly men (in their 70 s and 80 s) for whom the diagnosis was made during the evaluation of incidental symptoms suggestive of endocrinopathy. The first had hyponatremia; the other two had gynaecomastia and features of hypogonadism noted during admission for various acute medical problems. With respect to their genetic results; the first had a male karyotype with balanced reciprocal translocation between the long arm of chromosome 4 and the short arm of chromosome 7. The second case had a male karotype with one normal X chromosome and an isochrome for the short arm of the Y chromosome. The third case was an XX male with unbalanced translocation between the X & Y chromosomes with retention of the SRY locus.Conclusion: Hypergonadotrophic hypogonadism in the elderly, may be due to chromosomal aberrations, resulting in heterogeneous and diverse clinical phenotypes. Vigilance must be exercised when seeing cases with subtle clinical findings. This report suggests that in selected cases of adult hypergonadotropic hypogonadism, chromosomal analysis may be indicated.
KW - Humans
KW - Male
KW - Aged
KW - Chromosome Aberrations
KW - Hypogonadism/diagnosis
KW - Klinefelter Syndrome/diagnosis
KW - Karyotyping
KW - Gynecomastia
UR - http://www.scopus.com/inward/record.url?scp=85159678253&partnerID=8YFLogxK
U2 - 10.1186/s12902-023-01359-6
DO - 10.1186/s12902-023-01359-6
M3 - Article
C2 - 37198592
SN - 1472-6823
VL - 23
JO - BMC Endocrine Disorders
JF - BMC Endocrine Disorders
M1 - 110
ER -