Hypertension fails to disrupt white matter integrity in young or aged Fisher (F44) Cyp1a1Ren2 transgenic rats

Philip R. Holland, Mercede A. Pannozzo, Mark E. Bastin, Alison D. McNeilly, Karen J. Ferguson, Sarah Caughey, Maurits A. Jansen, Gavin D. Merrifield, Ian Marshall, John J. Mullins, Joanna M. Wardlaw, Calum Sutherland, Karen Horsburgh

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    6 Citations (Scopus)

    Abstract

    Hypertension is linked with an increased risk of white matter hyperintensities; however, recent findings have questioned this association. We examined whether hypertension and additional cerebrovascular risk factors impacted on white matter integrity in an inducible hypertensive rat. No white matter hyperintensities were observed on magnetic resonance imaging either alone or in conjunction with ageing and high-fat diet. Aged hypertensive rats that were fed a high-fat diet had moderately reduced fractional anisotropy in the corpus callosum with no overt pathological features. Herein we show that moderate hypertension alone or with additional risk factors has minimal impact on white matter integrity in this model.Journal of Cerebral Blood Flow & Metabolism advance online publication, 19 November 2014; doi:10.1038/jcbfm.2014.201.

    Original languageEnglish
    Pages (from-to)188-192
    Number of pages5
    JournalJournal of Cerebral Blood Flow and Metabolism
    Volume35
    Issue number2
    Early online date19 Nov 2014
    DOIs
    Publication statusPublished - Feb 2015

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    Sutherland, Calum

    • Cellular Medicine - Professor (Teaching and Research) & Professor of Molecular and Cellular Diabetes

    Person: Academic

    Cite this

    Holland, P. R., Pannozzo, M. A., Bastin, M. E., McNeilly, A. D., Ferguson, K. J., Caughey, S., Jansen, M. A., Merrifield, G. D., Marshall, I., Mullins, J. J., Wardlaw, J. M., Sutherland, C., & Horsburgh, K. (2015). Hypertension fails to disrupt white matter integrity in young or aged Fisher (F44) Cyp1a1Ren2 transgenic rats. Journal of Cerebral Blood Flow and Metabolism, 35(2), 188-192. https://doi.org/10.1038/jcbfm.2014.201