Neuroendocrine activation may be an important adjunctive mechanism for left ventricular hypertrophy (LVH) development. Controversy exists to as to whether LVH regression occurs due to blood pressure (BP) reduction alone or if adjunctive mechanisms play a role. We planned to test the hypothesis that for a similar BP reduction, LVH regression would be greater using a drug combination selected specifically to reduce neuroendocrine activity compared with one that did not.
Burns, J., Ball, S. G., Worthy, G., Struthers, A. D., Mary, D. A. S. G., & Greenwood, J. P. (2012). Hypertensive left ventricular hypertrophy: a mechanistic approach to optimizing regression assessed by cardiovascular magnetic resonance. Journal of Hypertension, 30(10), 2039-46. https://doi.org/10.1097/HJH.0b013e328356b850