Hyperuricemia and adverse outcomes in cardiovascular disease: potential for therapeutic intervention

Andrew R. Gavin, Allan D. Struthers

    Research output: Contribution to journalArticlepeer-review

    19 Citations (Scopus)


    High uric acid levels are associated with increased morbidity and mortality rates in cardiovascular disease. In this article we explore the relationship between cardiovascular disease and xanthine oxidase activity. We look at the evidence that uric acid and its production via the xanthine oxidase pathway, may directly contribute to this increased cardiovascular risk. We examine the relationship between uric acid and other established cardiovascular risk factors and look at the evidence that reducing uric acid production may have a beneficial impact on cardiovascular morbidity and mortality. We conclude that although there is currently insufficient evidence to recommend the routine use of xanthine oxidase inhibitors in those with cardiovascular disease and asymptomatic hyperuricemia, there is sufficient evidence to warrant a large scale morbidity and mortality trial.
    Original languageEnglish
    Pages (from-to)309-314
    Number of pages6
    JournalAmerican Journal of Cardiovascular Drugs
    Issue number5
    Publication statusPublished - Sept 2003


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