Hyposplenism and gastrointestinal diseases: significance and mechanisms

Abhinav Mathur, Mairi H. Mclean, Huan Cao, Mark A. Vickers

Research output: Contribution to journalReview articlepeer-review

5 Citations (Scopus)
204 Downloads (Pure)


Background: Functional hyposplenism is a recognized complication of several gastroenterological disorders, including coeliac and inflammatory bowel diseases, and is believed to contribute to the increased infection risk seen in these disorders.

Summary: The mechanisms of hyposplenism are poorly understood. In this article, we review possible mechanisms underlying development of functional hyposplenism and discuss implications for its management.

Key Messages: Identifying functional hyposplenism is important, as it may permit earlier recognition and treatment of serious infections through patient education and vaccination.

Original languageEnglish
Pages (from-to)290-298
Number of pages9
JournalDigestive Diseases
Issue number3
Early online date25 May 2021
Publication statusPublished - May 2022


  • hyposplenism
  • spleen
  • coeliac disease
  • inflammatory bowel disease
  • Hyposplenism
  • Inflammatory bowel disease
  • Spleen
  • Coeliac disease

ASJC Scopus subject areas

  • Gastroenterology


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