Hyposplenism and gastrointestinal diseases: significance and mechanisms

Abhinav Mathur, Mairi H. Mclean, Huan Cao, Mark A. Vickers

    Research output: Contribution to journalReview articlepeer-review

    8 Citations (Scopus)
    344 Downloads (Pure)

    Abstract

    Background: Functional hyposplenism is a recognized complication of several gastroenterological disorders, including coeliac and inflammatory bowel diseases, and is believed to contribute to the increased infection risk seen in these disorders.

    Summary: The mechanisms of hyposplenism are poorly understood. In this article, we review possible mechanisms underlying development of functional hyposplenism and discuss implications for its management.

    Key Messages: Identifying functional hyposplenism is important, as it may permit earlier recognition and treatment of serious infections through patient education and vaccination.

    Original languageEnglish
    Pages (from-to)290-298
    Number of pages9
    JournalDigestive Diseases
    Volume40
    Issue number3
    Early online date25 May 2021
    DOIs
    Publication statusPublished - May 2022

    Keywords

    • hyposplenism
    • spleen
    • coeliac disease
    • inflammatory bowel disease
    • Hyposplenism
    • Inflammatory bowel disease
    • Spleen
    • Coeliac disease

    ASJC Scopus subject areas

    • Gastroenterology

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