Hyposplenism and gastrointestinal diseases: significance and mechanisms

Abhinav Mathur, Mairi H. Mclean, Huan Cao, Mark A. Vickers

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Functional hyposplenism is a recognised complication of several gastroenterological disorders, including coeliac and inflammatory bowel diseases, and is believed to contribute to the increased infection risk seen in these disorders.

The mechanisms of hyposplenism are poorly understood. In this article, we review possible mechanisms underlying development of functional hyposplenism and discuss implications for its management.

Key messages
Identifying functional hyposplenism is important, as it may permit earlier recognition and treatment of serious infections through patient education and vaccination.
Original languageEnglish
JournalDigestive Diseases
Early online date25 May 2021
Publication statusE-pub ahead of print - 25 May 2021


  • hyposplenism
  • spleen
  • coeliac disease
  • inflammatory bowel disease

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