Hyposplenism and gastrointestinal diseases: significance and mechanisms

Abhinav Mathur; Mairi H. Mclean; Huan Cao; Mark A. Vickers

doi:10.1159/000517338

Hyposplenism and gastrointestinal diseases: significance and mechanisms

Abhinav Mathur, Mairi H. Mclean, Huan Cao, Mark A. Vickers

Research output: Contribution to journal › Review article › peer-review

10 Citations (Scopus)

505 Downloads (Pure)

Abstract

Background: Functional hyposplenism is a recognized complication of several gastroenterological disorders, including coeliac and inflammatory bowel diseases, and is believed to contribute to the increased infection risk seen in these disorders.

Summary: The mechanisms of hyposplenism are poorly understood. In this article, we review possible mechanisms underlying development of functional hyposplenism and discuss implications for its management.

Key Messages: Identifying functional hyposplenism is important, as it may permit earlier recognition and treatment of serious infections through patient education and vaccination.

Original language	English
Pages (from-to)	290-298
Number of pages	9
Journal	Digestive Diseases
Volume	40
Issue number	3
Early online date	25 May 2021
DOIs	https://doi.org/10.1159/000517338
Publication status	Published - May 2022

Keywords

hyposplenism
spleen
coeliac disease
inflammatory bowel disease
Hyposplenism
Inflammatory bowel disease
Spleen
Coeliac disease

ASJC Scopus subject areas

Gastroenterology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1159/000517338Licence: CC BY

Final published versionFinal published version, 553 KBLicence: CC BY

Cite this

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title = "Hyposplenism and gastrointestinal diseases: significance and mechanisms",

abstract = "Background: Functional hyposplenism is a recognized complication of several gastroenterological disorders, including coeliac and inflammatory bowel diseases, and is believed to contribute to the increased infection risk seen in these disorders.Summary: The mechanisms of hyposplenism are poorly understood. In this article, we review possible mechanisms underlying development of functional hyposplenism and discuss implications for its management.Key Messages: Identifying functional hyposplenism is important, as it may permit earlier recognition and treatment of serious infections through patient education and vaccination.",

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author = "Abhinav Mathur and Mclean, \{Mairi H.\} and Huan Cao and Vickers, \{Mark A.\}",

note = "Funding Information: Wellcome Trust Grant number 0934847/Z/10/Z. {\textcopyright} 2021 The Author(s). Published by S. Karger AG, Basel ",

year = "2022",

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doi = "10.1159/000517338",

language = "English",

volume = "40",

pages = "290--298",

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}

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T1 - Hyposplenism and gastrointestinal diseases

T2 - significance and mechanisms

AU - Mathur, Abhinav

AU - Mclean, Mairi H.

AU - Cao, Huan

AU - Vickers, Mark A.

PY - 2022/5

Y1 - 2022/5

N2 - Background: Functional hyposplenism is a recognized complication of several gastroenterological disorders, including coeliac and inflammatory bowel diseases, and is believed to contribute to the increased infection risk seen in these disorders.Summary: The mechanisms of hyposplenism are poorly understood. In this article, we review possible mechanisms underlying development of functional hyposplenism and discuss implications for its management.Key Messages: Identifying functional hyposplenism is important, as it may permit earlier recognition and treatment of serious infections through patient education and vaccination.

AB - Background: Functional hyposplenism is a recognized complication of several gastroenterological disorders, including coeliac and inflammatory bowel diseases, and is believed to contribute to the increased infection risk seen in these disorders.Summary: The mechanisms of hyposplenism are poorly understood. In this article, we review possible mechanisms underlying development of functional hyposplenism and discuss implications for its management.Key Messages: Identifying functional hyposplenism is important, as it may permit earlier recognition and treatment of serious infections through patient education and vaccination.

KW - hyposplenism

KW - spleen

KW - coeliac disease

KW - inflammatory bowel disease

KW - Hyposplenism

KW - Inflammatory bowel disease

KW - Spleen

KW - Coeliac disease

UR - https://www.scopus.com/pages/publications/85130005216

U2 - 10.1159/000517338

DO - 10.1159/000517338

M3 - Review article

C2 - 34034254

SN - 0257-2753

VL - 40

SP - 290

EP - 298

JO - Digestive Diseases

JF - Digestive Diseases

IS - 3

ER -

Hyposplenism and gastrointestinal diseases: significance and mechanisms

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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