Hypoxia activates IKK-NF-κB and the immune response in Drosophila melanogaster

Daniel Bandarra, John Biddlestone, Sharon Mudie, H. Arno Muller, Sonia Rocha (Lead / Corresponding author)

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    29 Citations (Scopus)
    198 Downloads (Pure)


    Hypoxia, or low oxygen availability, is an important physiological and
    pathological stimulus for multicellular organisms. Molecularly, hypoxia
    activates a transcriptional programme directed at restoration of oxygen
    homoeostasis and cellular survival. In mammalian cells, hypoxia not only
    activates the HIF (hypoxia-inducible factor) family, but also
    additional transcription factors such as NF-?B (nuclear factor ?B). Here
    we show that hypoxia activates the IKK–NF-?B [I?B (inhibitor of nuclear
    factor ?B)–NF-?B] pathway and the immune response in Drosophila melanogaster.
    We show that NF-?B activation is required for organism survival in
    hypoxia. Finally, we identify a role for the tumour suppressor Cyld, as a
    negative regulator of NF-?B in response to hypoxia in Drosophila.
    The results indicate that hypoxia activation of the IKK–NF-?B pathway
    and the immune response is an important and evolutionary conserved

    Original languageEnglish
    Article numbere00127
    Pages (from-to)429-440
    Number of pages12
    JournalBioscience Reports
    Issue number4
    Publication statusPublished - 2014


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