Hypoxia Induced NF-κB

Laura D'Ignazio, Sonia Rocha (Lead / Corresponding author)

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    104 Citations (Scopus)
    148 Downloads (Pure)

    Abstract

    As Nuclear Factor-κB (NF-κB) is a major transcription factor responding to cellular stress, it is perhaps not surprising that is activated by hypoxia, or decreased oxygen availability. However, how NF-κB becomes activated in hypoxia is still not completely understood. Several mechanisms have been proposed and this review will focus on the main findings highlighting the molecules that have been identified in the process of hypoxia induced NF-κB. In addition, we will discuss the role of NF-κB in the control of the cellular response to hypoxia.

    Original languageEnglish
    Article number10
    Number of pages8
    JournalCells
    Volume5
    Issue number1
    DOIs
    Publication statusPublished - 8 Mar 2016

    Keywords

    • Hypoxia
    • NF-κB
    • IKK
    • HIF-1
    • PHDs
    • FIH
    • TAK
    • ubiquitin

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