Hypoxia Induced NF-κB

Laura D'Ignazio; Sonia Rocha

doi:10.3390/cells5010010

Hypoxia Induced NF-κB

Laura D'Ignazio, Sonia Rocha (Lead / Corresponding author)

Research output: Contribution to journal › Article › peer-review

111 Citations (Scopus)

167 Downloads (Pure)

Abstract

As Nuclear Factor-κB (NF-κB) is a major transcription factor responding to cellular stress, it is perhaps not surprising that is activated by hypoxia, or decreased oxygen availability. However, how NF-κB becomes activated in hypoxia is still not completely understood. Several mechanisms have been proposed and this review will focus on the main findings highlighting the molecules that have been identified in the process of hypoxia induced NF-κB. In addition, we will discuss the role of NF-κB in the control of the cellular response to hypoxia.

Original language	English
Article number	10
Number of pages	8
Journal	Cells
Volume	5
Issue number	1
DOIs	https://doi.org/10.3390/cells5010010
Publication status	Published - 8 Mar 2016

Keywords

Hypoxia
NF-κB
IKK
HIF-1
PHDs
FIH
TAK
ubiquitin

Access to Document

10.3390/cells5010010Licence: CC BY

cells-05-00010Final published version, 562 KBLicence: CC BY

Cite this

@article{d069c537c49c45deb67752704a898f3e,

title = "Hypoxia Induced NF-κB",

abstract = "As Nuclear Factor-κB (NF-κB) is a major transcription factor responding to cellular stress, it is perhaps not surprising that is activated by hypoxia, or decreased oxygen availability. However, how NF-κB becomes activated in hypoxia is still not completely understood. Several mechanisms have been proposed and this review will focus on the main findings highlighting the molecules that have been identified in the process of hypoxia induced NF-κB. In addition, we will discuss the role of NF-κB in the control of the cellular response to hypoxia.",

keywords = "Hypoxia, NF-κB, IKK, HIF-1, PHDs, FIH, TAK, ubiquitin",

author = "Laura D'Ignazio and Sonia Rocha",

year = "2016",

month = mar,

day = "8",

doi = "10.3390/cells5010010",

language = "English",

volume = "5",

journal = "Cells",

issn = "2073-4409",

publisher = "MDPI",

number = "1",

}

TY - JOUR

T1 - Hypoxia Induced NF-κB

AU - D'Ignazio, Laura

AU - Rocha, Sonia

PY - 2016/3/8

Y1 - 2016/3/8

N2 - As Nuclear Factor-κB (NF-κB) is a major transcription factor responding to cellular stress, it is perhaps not surprising that is activated by hypoxia, or decreased oxygen availability. However, how NF-κB becomes activated in hypoxia is still not completely understood. Several mechanisms have been proposed and this review will focus on the main findings highlighting the molecules that have been identified in the process of hypoxia induced NF-κB. In addition, we will discuss the role of NF-κB in the control of the cellular response to hypoxia.

AB - As Nuclear Factor-κB (NF-κB) is a major transcription factor responding to cellular stress, it is perhaps not surprising that is activated by hypoxia, or decreased oxygen availability. However, how NF-κB becomes activated in hypoxia is still not completely understood. Several mechanisms have been proposed and this review will focus on the main findings highlighting the molecules that have been identified in the process of hypoxia induced NF-κB. In addition, we will discuss the role of NF-κB in the control of the cellular response to hypoxia.

KW - Hypoxia

KW - NF-κB

KW - IKK

KW - HIF-1

KW - PHDs

KW - FIH

KW - TAK

KW - ubiquitin

U2 - 10.3390/cells5010010

DO - 10.3390/cells5010010

M3 - Article

C2 - 27005664

SN - 2073-4409

VL - 5

JO - Cells

JF - Cells

IS - 1

M1 - 10

ER -

Hypoxia Induced NF-κB

Abstract

Keywords

Access to Document

Fingerprint

Cite this