Hypoxia Induced NF-κB

Laura D'Ignazio, Sonia Rocha (Lead / Corresponding author)

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Abstract

As Nuclear Factor-κB (NF-κB) is a major transcription factor responding to cellular stress, it is perhaps not surprising that is activated by hypoxia, or decreased oxygen availability. However, how NF-κB becomes activated in hypoxia is still not completely understood. Several mechanisms have been proposed and this review will focus on the main findings highlighting the molecules that have been identified in the process of hypoxia induced NF-κB. In addition, we will discuss the role of NF-κB in the control of the cellular response to hypoxia.

Original languageEnglish
Article number10
Number of pages8
JournalCells
Volume5
Issue number1
DOIs
Publication statusPublished - 8 Mar 2016

Keywords

  • Hypoxia
  • NF-κB
  • IKK
  • HIF-1
  • PHDs
  • FIH
  • TAK
  • ubiquitin

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    D'Ignazio, L., & Rocha, S. (2016). Hypoxia Induced NF-κB. Cells, 5(1), [10]. https://doi.org/10.3390/cells5010010