Identification and characterization of a novel human FOXK1 gene in silico.

Jeffrey T.J. Huang, Vivian Lee

    Research output: Contribution to journalArticlepeer-review

    10 Citations (Scopus)

    Abstract

    We describe here the identification and characterization of a human forkhead box gene, FOXK1, that encodes predicted proteins most homologous to the mouse myocyte nuclear factor (MNF)/forkhead box K1 (FoxK1). Human FOXK1 is located at the chromosomal position 7p22. Two transcript variants, FOXK1a and FOXK1b, containing the divergent 5'-ends are identified. Sequence comparison indicated that the human FOXK1 proteins share 66-74% amino acid identity (99% identity in the forkhead domain) with their mouse ortholog. The in silico expression analysis showed FOXK1 expression in immature tissues of brain, eye, heart, lung and thymus. In adults, FOXK1 was predominantly expressed in many malignant tissues, in particular in the tumors of brain, colon and lymph node. This gene is therefore implicated in the process of both normal and neoplastic development.

    Original languageEnglish
    Pages (from-to)751-757
    Number of pages7
    JournalInternational Journal of Oncology
    Volume25
    Issue number3
    DOIs
    Publication statusPublished - Sep 2004

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