Projects per year
Abstract
Visceral leishmaniasis (VL) affects millions of people across the world, largely in developing nations. It is fatal if left untreated and the current treatments are inadequate. As such, there is an urgent need for new, improved medicines. In this paper, we describe the identification of a 6-amino-N-(piperidin-4-yl)-1H-pyrazolo[3,4-d]pyrimidine scaffold and its optimization to give compounds which showed efficacy when orally dosed in a mouse model of VL.
Original language | English |
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Pages (from-to) | 1168-1177 |
Number of pages | 10 |
Journal | RSC Medicinal Chemistry |
Volume | 11 |
Issue number | 10 |
Early online date | 6 Aug 2020 |
DOIs | |
Publication status | Published - 21 Oct 2020 |
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Dive into the research topics of 'Identification of 6-amino-1H-pyrazolo[3,4-d]pyrimidines with in vivo efficacy against visceral leishmaniasis'. Together they form a unique fingerprint.Projects
- 2 Finished
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A Translational Engine for Biomedical Discoveries (Strategic Grant)
1/01/13 → 30/09/15
Project: Research
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Discovery and Development of Drug Candidates for Neglected Diseases (joint with industrial partner)
Brenk, R., Fairlamb, A., Ferguson, M., Field, M., Gilbert, I., Gray, D., Hopkins, A., Horn, D., Read, K., Wyatt, P. & van Aalten, D.
1/02/11 → 1/07/17
Project: Research