Identification of a third form of protein phosphatase 1 in rabbit skeletal muscle that is associated with myosin

Alexander A K Chisholm, Philip Cohen

    Research output: Contribution to journalArticle

    40 Citations (Scopus)

    Abstract

    A third form of protein phosphatase 1 has been identified in skeletal muscle which is distinct from the species composed of the catalytic subunit complexed to the glycogen-binding subunit (protein phosphatase 1G) or inhibitor-2 (protein phosphatase 1I). The third form has an apparent molecular mass of 110 kDa, is not immunoprecipitated by antibody prepared against the glycogen-binding subunit, does not interact with glycogen and is devoid of inhibitor-2. It is tightly bound to myosin and is therefore termed protein phosphatase 1M.

    Original languageEnglish
    Pages (from-to)392-400
    Number of pages9
    JournalBBA - Molecular Cell Research
    Volume968
    Issue number3
    DOIs
    Publication statusPublished - 11 Mar 1988

    Keywords

    • (Skeletal muscle)
    • Glycogen binding
    • Glycogen metabolism
    • Myosin binding
    • Protein phosphatase 1

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