Identification of a third form of protein phosphatase 1 in rabbit skeletal muscle that is associated with myosin

Alexander A K Chisholm; Philip Cohen

doi:10.1016/0167-4889(88)90032-8

Identification of a third form of protein phosphatase 1 in rabbit skeletal muscle that is associated with myosin

Alexander A K Chisholm, Philip Cohen

Research output: Contribution to journal › Article

40 Citations (Scopus)

Abstract

A third form of protein phosphatase 1 has been identified in skeletal muscle which is distinct from the species composed of the catalytic subunit complexed to the glycogen-binding subunit (protein phosphatase 1_G) or inhibitor-2 (protein phosphatase 1_I). The third form has an apparent molecular mass of 110 kDa, is not immunoprecipitated by antibody prepared against the glycogen-binding subunit, does not interact with glycogen and is devoid of inhibitor-2. It is tightly bound to myosin and is therefore termed protein phosphatase 1_M.

Original language	English
Pages (from-to)	392-400
Number of pages	9
Journal	BBA - Molecular Cell Research
Volume	968
Issue number	3
DOIs	https://doi.org/10.1016/0167-4889(88)90032-8
Publication status	Published - 11 Mar 1988

Keywords

(Skeletal muscle)
Glycogen binding
Glycogen metabolism
Myosin binding
Protein phosphatase 1

Access to Document

10.1016/0167-4889(88)90032-8Licence: Elsevier User Licence

Link to publication in Scopus

Fingerprint Dive into the research topics of 'Identification of a third form of protein phosphatase 1 in rabbit skeletal muscle that is associated with myosin'. Together they form a unique fingerprint.

Cite this

@article{665bfb2e7a80400da90def163bc79dc6,

title = "Identification of a third form of protein phosphatase 1 in rabbit skeletal muscle that is associated with myosin",

abstract = "A third form of protein phosphatase 1 has been identified in skeletal muscle which is distinct from the species composed of the catalytic subunit complexed to the glycogen-binding subunit (protein phosphatase 1G) or inhibitor-2 (protein phosphatase 1I). The third form has an apparent molecular mass of 110 kDa, is not immunoprecipitated by antibody prepared against the glycogen-binding subunit, does not interact with glycogen and is devoid of inhibitor-2. It is tightly bound to myosin and is therefore termed protein phosphatase 1M.",

keywords = "(Skeletal muscle), Glycogen binding, Glycogen metabolism, Myosin binding, Protein phosphatase 1",

author = "Chisholm, {Alexander A K} and Philip Cohen",

year = "1988",

month = mar,

day = "11",

doi = "10.1016/0167-4889(88)90032-8",

language = "English",

volume = "968",

pages = "392--400",

journal = "Biochimica et Biophysica Acta. Molecular Cell Research",

issn = "0167-4889",

publisher = "Elsevier",

number = "3",

}

TY - JOUR

T1 - Identification of a third form of protein phosphatase 1 in rabbit skeletal muscle that is associated with myosin

AU - Chisholm, Alexander A K

AU - Cohen, Philip

PY - 1988/3/11

Y1 - 1988/3/11

N2 - A third form of protein phosphatase 1 has been identified in skeletal muscle which is distinct from the species composed of the catalytic subunit complexed to the glycogen-binding subunit (protein phosphatase 1G) or inhibitor-2 (protein phosphatase 1I). The third form has an apparent molecular mass of 110 kDa, is not immunoprecipitated by antibody prepared against the glycogen-binding subunit, does not interact with glycogen and is devoid of inhibitor-2. It is tightly bound to myosin and is therefore termed protein phosphatase 1M.

AB - A third form of protein phosphatase 1 has been identified in skeletal muscle which is distinct from the species composed of the catalytic subunit complexed to the glycogen-binding subunit (protein phosphatase 1G) or inhibitor-2 (protein phosphatase 1I). The third form has an apparent molecular mass of 110 kDa, is not immunoprecipitated by antibody prepared against the glycogen-binding subunit, does not interact with glycogen and is devoid of inhibitor-2. It is tightly bound to myosin and is therefore termed protein phosphatase 1M.

KW - (Skeletal muscle)

KW - Glycogen binding

KW - Glycogen metabolism

KW - Myosin binding

KW - Protein phosphatase 1

UR - http://www.scopus.com/inward/record.url?scp=0023878243&partnerID=8YFLogxK

U2 - 10.1016/0167-4889(88)90032-8

DO - 10.1016/0167-4889(88)90032-8

M3 - Article

C2 - 2830909

AN - SCOPUS:0023878243

VL - 968

SP - 392

EP - 400

JO - Biochimica et Biophysica Acta. Molecular Cell Research

JF - Biochimica et Biophysica Acta. Molecular Cell Research

SN - 0167-4889

IS - 3

ER -