Identification of high levels of protein phosphatase-1 in rat liver nuclei

Jeff Kuret; Heather Bell; Philip Cohen

doi:10.1016/0014-5793(86)80741-4

Identification of high levels of protein phosphatase-1 in rat liver nuclei

Jeff Kuret, Heather Bell, Philip Cohen

Research output: Contribution to journal › Article › peer-review

63 Citations (Scopus)

Abstract

Rat liver nuclei contain a protein phosphatase that is indistinguishable from the catalytic subunit of protein phosphatase-1 in its molecular mass, sensitivity to inhibitor-1 and inhibitor-2 and specificity for the β-subunit of phosphorylase kinase. This activity is not bound to the outer nuclear membrane, but located within the nucleus. The average level of protein phosphatase-1 activity in nuclei is at least 5-fold higher than its average extranuclear concentration.

Original language	English
Pages (from-to)	197-202
Number of pages	6
Journal	FEBS Letters
Volume	203
Issue number	2
DOIs	https://doi.org/10.1016/0014-5793(86)80741-4
Publication status	Published - 28 Jul 1986

Keywords

(Rat liver)
Metabolic regulation
Nucleus
Protein phosphatase
Protein phosphorylation

ASJC Scopus subject areas

Structural Biology
Biophysics
Biochemistry
Molecular Biology
Genetics
Cell Biology

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Cite this

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abstract = "Rat liver nuclei contain a protein phosphatase that is indistinguishable from the catalytic subunit of protein phosphatase-1 in its molecular mass, sensitivity to inhibitor-1 and inhibitor-2 and specificity for the β-subunit of phosphorylase kinase. This activity is not bound to the outer nuclear membrane, but located within the nucleus. The average level of protein phosphatase-1 activity in nuclei is at least 5-fold higher than its average extranuclear concentration.",

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AU - Bell, Heather

AU - Cohen, Philip

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AB - Rat liver nuclei contain a protein phosphatase that is indistinguishable from the catalytic subunit of protein phosphatase-1 in its molecular mass, sensitivity to inhibitor-1 and inhibitor-2 and specificity for the β-subunit of phosphorylase kinase. This activity is not bound to the outer nuclear membrane, but located within the nucleus. The average level of protein phosphatase-1 activity in nuclei is at least 5-fold higher than its average extranuclear concentration.

KW - (Rat liver)

KW - Metabolic regulation

KW - Nucleus

KW - Protein phosphatase

KW - Protein phosphorylation

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ER -

Identification of high levels of protein phosphatase-1 in rat liver nuclei

Abstract

Keywords

ASJC Scopus subject areas

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