Identification of high levels of protein phosphatase-1 in rat liver nuclei

Jeff Kuret, Heather Bell, Philip Cohen

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    Abstract

    Rat liver nuclei contain a protein phosphatase that is indistinguishable from the catalytic subunit of protein phosphatase-1 in its molecular mass, sensitivity to inhibitor-1 and inhibitor-2 and specificity for the β-subunit of phosphorylase kinase. This activity is not bound to the outer nuclear membrane, but located within the nucleus. The average level of protein phosphatase-1 activity in nuclei is at least 5-fold higher than its average extranuclear concentration.

    Original languageEnglish
    Pages (from-to)197-202
    Number of pages6
    JournalFEBS Letters
    Volume203
    Issue number2
    DOIs
    Publication statusPublished - 28 Jul 1986

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    Keywords

    • (Rat liver)
    • Metabolic regulation
    • Nucleus
    • Protein phosphatase
    • Protein phosphorylation

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