Identification of high levels of protein phosphatase-1 in rat liver nuclei

TY - JOUR

T1 - Identification of high levels of protein phosphatase-1 in rat liver nuclei

AU - Kuret, Jeff

AU - Bell, Heather

AU - Cohen, Philip

PY - 1986/7/28

Y1 - 1986/7/28

N2 - Rat liver nuclei contain a protein phosphatase that is indistinguishable from the catalytic subunit of protein phosphatase-1 in its molecular mass, sensitivity to inhibitor-1 and inhibitor-2 and specificity for the β-subunit of phosphorylase kinase. This activity is not bound to the outer nuclear membrane, but located within the nucleus. The average level of protein phosphatase-1 activity in nuclei is at least 5-fold higher than its average extranuclear concentration.

AB - Rat liver nuclei contain a protein phosphatase that is indistinguishable from the catalytic subunit of protein phosphatase-1 in its molecular mass, sensitivity to inhibitor-1 and inhibitor-2 and specificity for the β-subunit of phosphorylase kinase. This activity is not bound to the outer nuclear membrane, but located within the nucleus. The average level of protein phosphatase-1 activity in nuclei is at least 5-fold higher than its average extranuclear concentration.

KW - (Rat liver)

KW - Metabolic regulation

KW - Nucleus

KW - Protein phosphatase

KW - Protein phosphorylation

UR - https://www.scopus.com/pages/publications/0022450582

U2 - 10.1016/0014-5793(86)80741-4

DO - 10.1016/0014-5793(86)80741-4

M3 - Article

C2 - 3015674

AN - SCOPUS:0022450582

SN - 0014-5793

VL - 203

SP - 197

EP - 202

JO - FEBS Letters

JF - FEBS Letters

IS - 2

ER -