TY - JOUR
T1 - Identification of novel inhibitors of UDP-Glc 4 '-epimerase, a validated drug target for African sleeping sickness
AU - Urbaniak, Michael D.
AU - Tabudravu, Jioji N.
AU - Msaki, Aichi
AU - Matera, Kathy Mansfield
AU - Brenk, Ruth
AU - Jaspars, Marcel
AU - Ferguson, Michael A. J.
PY - 2006/11/15
Y1 - 2006/11/15
N2 - Novel inhibitors of Trypanosoma brucei and mammalian UDP-Glc 4'-epimerase were identified by screening a small library of natural products and commercially available drug-like molecules. The inhibitors possess low micromolar potency against the T brucei and human enzymes in vitro, display a degree of selectivity between the two enzymes, and are cytotoxic to cultured T. brucei and mammalian cells. (c) 2006 Elsevier Ltd. All rights reserved.
AB - Novel inhibitors of Trypanosoma brucei and mammalian UDP-Glc 4'-epimerase were identified by screening a small library of natural products and commercially available drug-like molecules. The inhibitors possess low micromolar potency against the T brucei and human enzymes in vitro, display a degree of selectivity between the two enzymes, and are cytotoxic to cultured T. brucei and mammalian cells. (c) 2006 Elsevier Ltd. All rights reserved.
U2 - 10.1016/j.bmcl.2006.08.091
DO - 10.1016/j.bmcl.2006.08.091
M3 - Article
SN - 0960-894X
VL - 16
SP - 5744
EP - 5747
JO - Bioorganic & Medicinal Chemistry Letters
JF - Bioorganic & Medicinal Chemistry Letters
IS - 22
ER -
