Projects per year
Methods: 5033 plasma proteins were measured in 1061 cognitively normal individuals (628 female and 433 male), nearly 90% of whom had magnetic resonance imaging (MRI) measures of hippocampus volume (as N) and white matter hyperintensities (as V).
Results: Protein differential analysis and co-expression network analysis revealed several proteins and modules associated with N and V respectively and such associations were affected by sex. Furthermore, four proteins mediated sex-related difference in neurodegeneration and one protein mediated such difference in vascular damage.
Discussion: The identified proteins could help to select cognitively normal individuals with N and V pathology for AD clinical trials and provide tractable targets for further mechanistic studies, leading to sex-specific therapeutic strategies
|Number of pages||12|
|Journal||Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring|
|Early online date||1 Sept 2021|
|Publication status||Published - 2021|
- plasma proteomics
- vascular damage
- sex-related difference
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MICA: InterdisciPlInary Collaboration for EfficienT and Effective Use of Clinical Images in Big Data Health Care RESearch: PICTURES (Programme Grant) (Joint with Universities of Edinburgh and Abertay)
1/08/19 → 28/02/25