Identification of potent and selective oxytocin antagonists. Part 2: further investigation of benzofuran derivatives

Paul G. Wyatt, Michael J. Allen, Josie Chilcott, Christopher J. Gardner, David G. Livermore, Jackie E. Mordaunt, Fabrizio Nerozzi, Mamta Patel, Marion J. Perren, Gordon G. Weingarten, Shalia Shabbir, Patrick M. Woollard, Ping Zhou

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    Abstract

    The paper covers continuing efforts to discover novel, potent and selective oxytocin antagonists. Further benzofuran derivatives with potent oxytocin antagonist activity and good pharmacokinetic parameters are reported. Efforts to improve the in vivo activity of the series are described.
    Original languageEnglish
    Pages (from-to)1405-1411
    Number of pages7
    JournalBioorganic & Medicinal Chemistry Letters
    Volume12
    Issue number10
    DOIs
    Publication statusPublished - May 2002

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    Wyatt, P. G., Allen, M. J., Chilcott, J., Gardner, C. J., Livermore, D. G., Mordaunt, J. E., Nerozzi, F., Patel, M., Perren, M. J., Weingarten, G. G., Shabbir, S., Woollard, P. M., & Zhou, P. (2002). Identification of potent and selective oxytocin antagonists. Part 2: further investigation of benzofuran derivatives. Bioorganic & Medicinal Chemistry Letters, 12(10), 1405-1411. https://doi.org/10.1016/S0960-894X(02)00160-9