Identification of potent and selective oxytocin antagonists. Part 2:  further investigation of benzofuran derivatives

Paul G. Wyatt; Michael J. Allen; Josie Chilcott; Christopher J. Gardner; David G. Livermore; Jackie E. Mordaunt; Fabrizio Nerozzi; Mamta Patel; Marion J. Perren; Gordon G. Weingarten; Shalia Shabbir; Patrick M. Woollard; Ping Zhou

doi:10.1016/S0960-894X(02)00160-9

Identification of potent and selective oxytocin antagonists. Part 2: further investigation of benzofuran derivatives

Paul G. Wyatt
, Michael J. Allen
, Josie Chilcott
, Christopher J. Gardner
, David G. Livermore
, Jackie E. Mordaunt
, Fabrizio Nerozzi
, Mamta Patel
, Marion J. Perren
, Gordon G. Weingarten
, Shalia Shabbir
, Patrick M. Woollard
, Ping Zhou

Research output: Contribution to journal › Article › peer-review

48 Citations (Scopus)

Abstract

The paper covers continuing efforts to discover novel, potent and selective oxytocin antagonists. Further benzofuran derivatives with potent oxytocin antagonist activity and good pharmacokinetic parameters are reported. Efforts to improve the in vivo activity of the series are described.

Original language	English
Pages (from-to)	1405-1411
Number of pages	7
Journal	Bioorganic & Medicinal Chemistry Letters
Volume	12
Issue number	10
DOIs	https://doi.org/10.1016/S0960-894X(02)00160-9
Publication status	Published - May 2002

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Wyatt, P. G., Allen, M. J., Chilcott, J., Gardner, C. J., Livermore, D. G., Mordaunt, J. E., Nerozzi, F., Patel, M., Perren, M. J., Weingarten, G. G., Shabbir, S., Woollard, P. M., & Zhou, P. (2002). Identification of potent and selective oxytocin antagonists. Part 2: further investigation of benzofuran derivatives. Bioorganic & Medicinal Chemistry Letters, 12(10), 1405-1411. https://doi.org/10.1016/S0960-894X(02)00160-9

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abstract = "The paper covers continuing efforts to discover novel, potent and selective oxytocin antagonists. Further benzofuran derivatives with potent oxytocin antagonist activity and good pharmacokinetic parameters are reported. Efforts to improve the in vivo activity of the series are described.",

author = "Wyatt, \{Paul G.\} and Allen, \{Michael J.\} and Josie Chilcott and Gardner, \{Christopher J.\} and Livermore, \{David G.\} and Mordaunt, \{Jackie E.\} and Fabrizio Nerozzi and Mamta Patel and Perren, \{Marion J.\} and Weingarten, \{Gordon G.\} and Shalia Shabbir and Woollard, \{Patrick M.\} and Ping Zhou",

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doi = "10.1016/S0960-894X(02)00160-9",

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journal = "Bioorganic \& Medicinal Chemistry Letters",

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Wyatt, PG, Allen, MJ, Chilcott, J, Gardner, CJ, Livermore, DG, Mordaunt, JE, Nerozzi, F, Patel, M, Perren, MJ, Weingarten, GG, Shabbir, S, Woollard, PM & Zhou, P 2002, 'Identification of potent and selective oxytocin antagonists. Part 2: further investigation of benzofuran derivatives', Bioorganic & Medicinal Chemistry Letters, vol. 12, no. 10, pp. 1405-1411. https://doi.org/10.1016/S0960-894X(02)00160-9

TY - JOUR

T1 - Identification of potent and selective oxytocin antagonists. Part 2

T2 - further investigation of benzofuran derivatives

AU - Wyatt, Paul G.

AU - Allen, Michael J.

AU - Chilcott, Josie

AU - Gardner, Christopher J.

AU - Livermore, David G.

AU - Mordaunt, Jackie E.

AU - Nerozzi, Fabrizio

AU - Patel, Mamta

AU - Perren, Marion J.

AU - Weingarten, Gordon G.

AU - Shabbir, Shalia

AU - Woollard, Patrick M.

AU - Zhou, Ping

N1 - dc.publisher: Elsevier

PY - 2002/5

Y1 - 2002/5

N2 - The paper covers continuing efforts to discover novel, potent and selective oxytocin antagonists. Further benzofuran derivatives with potent oxytocin antagonist activity and good pharmacokinetic parameters are reported. Efforts to improve the in vivo activity of the series are described.

AB - The paper covers continuing efforts to discover novel, potent and selective oxytocin antagonists. Further benzofuran derivatives with potent oxytocin antagonist activity and good pharmacokinetic parameters are reported. Efforts to improve the in vivo activity of the series are described.

U2 - 10.1016/S0960-894X(02)00160-9

DO - 10.1016/S0960-894X(02)00160-9

M3 - Article

SN - 0960-894X

VL - 12

SP - 1405

EP - 1411

JO - Bioorganic & Medicinal Chemistry Letters

JF - Bioorganic & Medicinal Chemistry Letters

IS - 10

ER -

Identification of potent and selective oxytocin antagonists. Part 2: further investigation of benzofuran derivatives

Abstract

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