Identification of sVSG117 as an immunodiagnostic antigen and evaluation of a dual-antigen lateral flow test for the diagnosis of human african trypanosomiasis

Lauren Sullivan; Jennifer Fleming; Lalitha Sastry; Angela Mehlert; Steven J Wall; Michael A J Ferguson

doi:10.1371/journal.pntd.0002976

Identification of sVSG117 as an immunodiagnostic antigen and evaluation of a dual-antigen lateral flow test for the diagnosis of human african trypanosomiasis

Lauren Sullivan, Jennifer Fleming, Lalitha Sastry, Angela Mehlert, Steven J Wall, Michael A J Ferguson (Lead / Corresponding author)

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13 Citations (Scopus)

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Abstract

The diagnosis of human African trypanosomiasis (HAT) caused by Trypanosoma brucei gambiense relies mainly on the Card Agglutination Test for Trypanosomiasis (CATT). There is no immunodiagnostic for HAT caused by T. b. rhodesiense. Our principle aim was to develop a prototype lateral flow test that might be an improvement on CATT.

Original language	English
Pages (from-to)	e2976
Journal	PLoS Neglected Tropical Diseases
Volume	8
Issue number	7
DOIs	https://doi.org/10.1371/journal.pntd.0002976
Publication status	Published - 17 Jul 2014

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© 2014 Sullivan et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited
Final published version, 485 KBLicence: CC BY

http://www.plosntds.org/article/info%3Adoi%2F10.1371%2Fjournal.pntd.0002976#abstract1

Protein Glycosylation in Trypanosomes: Defining and Exploiting a Biological System (Senior Investigator Award)
Ferguson, M. (Investigator)
1/10/13 → 30/06/23
Project: Research
A Translational Engine for Biomedical Discoveries (Strategic Grant)
Fairlamb, A. (Investigator) & Gilbert, I. (Investigator)
1/01/13 → 30/09/15
Project: Research

Ferguson, Michael
Person

Cite this

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title = "Identification of sVSG117 as an immunodiagnostic antigen and evaluation of a dual-antigen lateral flow test for the diagnosis of human african trypanosomiasis",

abstract = "The diagnosis of human African trypanosomiasis (HAT) caused by Trypanosoma brucei gambiense relies mainly on the Card Agglutination Test for Trypanosomiasis (CATT). There is no immunodiagnostic for HAT caused by T. b. rhodesiense. Our principle aim was to develop a prototype lateral flow test that might be an improvement on CATT.",

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AU - Sastry, Lalitha

AU - Mehlert, Angela

AU - Wall, Steven J

AU - Ferguson, Michael A J

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Identification of sVSG117 as an immunodiagnostic antigen and evaluation of a dual-antigen lateral flow test for the diagnosis of human african trypanosomiasis

Abstract

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Projects

Protein Glycosylation in Trypanosomes: Defining and Exploiting a Biological System (Senior Investigator Award)

A Translational Engine for Biomedical Discoveries (Strategic Grant)

Profiles

Ferguson, Michael

Cite this