Identification of the true human orthologue of the mouse Zp1 gene: evidence for greater complexity in the mammalian zona pellucida?

David C. Hughes; Christopher L. R. Barratt

doi:10.1016/S0167-4781(99)00181-5

Identification of the true human orthologue of the mouse Zp1 gene: evidence for greater complexity in the mammalian zona pellucida?

David C. Hughes (Lead / Corresponding author), Christopher L. R. Barratt

Undergraduate Medicine

Research output: Contribution to journal › Article › peer-review

103 Citations (Scopus)

Abstract

The mammalian zona pellucida is a mixture of glycoproteins, believed to be encoded by three distinct genes, ZP1/ZPB, ZP2/ZPA, and ZP3/ZPC. We have now determined that the true human orthologue of the mouse Zp1 gene is not ZPB, but that there is a distinct human ZP1 gene. Comparison of the human ZP1 and murine Zp1 genes indicates significant conservation of nucleotide and amino acid sequences, of intron-exon size and organisation, and of regulatory sequences. In addition, the mouse and human ZP1 genes are in a region of conserved synteny between human chromosome 11 and mouse chromosome 19.

Original language	English
Pages (from-to)	303-6
Number of pages	4
Journal	BBA - General Subjects
Volume	1447
Issue number	2-3
DOIs	https://doi.org/10.1016/S0167-4781(99)00181-5
Publication status	Published - 28 Oct 1999

Keywords

Animals
Base Sequence
Chromosome Mapping
Chromosomes, Human, Pair 11
Egg Proteins/genetics
Female
Humans
Membrane Glycoproteins/genetics
Mice
Molecular Sequence Data
Receptors, Cell Surface
Sequence Alignment
Sequence Analysis, DNA
Zona Pellucida/metabolism
Zona Pellucida Glycoproteins

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10.1016/S0167-4781(99)00181-5

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title = "Identification of the true human orthologue of the mouse Zp1 gene: evidence for greater complexity in the mammalian zona pellucida?",

abstract = "The mammalian zona pellucida is a mixture of glycoproteins, believed to be encoded by three distinct genes, ZP1/ZPB, ZP2/ZPA, and ZP3/ZPC. We have now determined that the true human orthologue of the mouse Zp1 gene is not ZPB, but that there is a distinct human ZP1 gene. Comparison of the human ZP1 and murine Zp1 genes indicates significant conservation of nucleotide and amino acid sequences, of intron-exon size and organisation, and of regulatory sequences. In addition, the mouse and human ZP1 genes are in a region of conserved synteny between human chromosome 11 and mouse chromosome 19.",

keywords = "Animals, Base Sequence, Chromosome Mapping, Chromosomes, Human, Pair 11, Egg Proteins/genetics, Female, Humans, Membrane Glycoproteins/genetics, Mice, Molecular Sequence Data, Receptors, Cell Surface, Sequence Alignment, Sequence Analysis, DNA, Zona Pellucida/metabolism, Zona Pellucida Glycoproteins",

author = "Hughes, {David C.} and Barratt, {Christopher L. R.}",

year = "1999",

month = oct,

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doi = "10.1016/S0167-4781(99)00181-5",

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T1 - Identification of the true human orthologue of the mouse Zp1 gene

T2 - evidence for greater complexity in the mammalian zona pellucida?

AU - Hughes, David C.

AU - Barratt, Christopher L. R.

PY - 1999/10/28

Y1 - 1999/10/28

N2 - The mammalian zona pellucida is a mixture of glycoproteins, believed to be encoded by three distinct genes, ZP1/ZPB, ZP2/ZPA, and ZP3/ZPC. We have now determined that the true human orthologue of the mouse Zp1 gene is not ZPB, but that there is a distinct human ZP1 gene. Comparison of the human ZP1 and murine Zp1 genes indicates significant conservation of nucleotide and amino acid sequences, of intron-exon size and organisation, and of regulatory sequences. In addition, the mouse and human ZP1 genes are in a region of conserved synteny between human chromosome 11 and mouse chromosome 19.

AB - The mammalian zona pellucida is a mixture of glycoproteins, believed to be encoded by three distinct genes, ZP1/ZPB, ZP2/ZPA, and ZP3/ZPC. We have now determined that the true human orthologue of the mouse Zp1 gene is not ZPB, but that there is a distinct human ZP1 gene. Comparison of the human ZP1 and murine Zp1 genes indicates significant conservation of nucleotide and amino acid sequences, of intron-exon size and organisation, and of regulatory sequences. In addition, the mouse and human ZP1 genes are in a region of conserved synteny between human chromosome 11 and mouse chromosome 19.

KW - Animals

KW - Base Sequence

KW - Chromosome Mapping

KW - Chromosomes, Human, Pair 11

KW - Egg Proteins/genetics

KW - Female

KW - Humans

KW - Membrane Glycoproteins/genetics

KW - Mice

KW - Molecular Sequence Data

KW - Receptors, Cell Surface

KW - Sequence Alignment

KW - Sequence Analysis, DNA

KW - Zona Pellucida/metabolism

KW - Zona Pellucida Glycoproteins

U2 - 10.1016/S0167-4781(99)00181-5

DO - 10.1016/S0167-4781(99)00181-5

M3 - Article

C2 - 10542331

SN - 0304-4165

VL - 1447

SP - 303

EP - 306

JO - BBA - General Subjects

JF - BBA - General Subjects

IS - 2-3

ER -

Identification of the true human orthologue of the mouse Zp1 gene: evidence for greater complexity in the mammalian zona pellucida?

Abstract

Keywords

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