Identification of the true human orthologue of the mouse Zp1 gene: evidence for greater complexity in the mammalian zona pellucida?

David C. Hughes (Lead / Corresponding author), Christopher L. R. Barratt

Research output: Contribution to journalArticlepeer-review

91 Citations (Scopus)

Abstract

The mammalian zona pellucida is a mixture of glycoproteins, believed to be encoded by three distinct genes, ZP1/ZPB, ZP2/ZPA, and ZP3/ZPC. We have now determined that the true human orthologue of the mouse Zp1 gene is not ZPB, but that there is a distinct human ZP1 gene. Comparison of the human ZP1 and murine Zp1 genes indicates significant conservation of nucleotide and amino acid sequences, of intron-exon size and organisation, and of regulatory sequences. In addition, the mouse and human ZP1 genes are in a region of conserved synteny between human chromosome 11 and mouse chromosome 19.

Original languageEnglish
Pages (from-to)303-6
Number of pages4
JournalBiochimica et Biophysica Acta: General Subjects
Volume1447
Issue number2-3
DOIs
Publication statusPublished - 28 Oct 1999

Keywords

  • Animals
  • Base Sequence
  • Chromosome Mapping
  • Chromosomes, Human, Pair 11
  • Egg Proteins/genetics
  • Female
  • Humans
  • Membrane Glycoproteins/genetics
  • Mice
  • Molecular Sequence Data
  • Receptors, Cell Surface
  • Sequence Alignment
  • Sequence Analysis, DNA
  • Zona Pellucida/metabolism
  • Zona Pellucida Glycoproteins

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