Abstract
The mammalian zona pellucida is a mixture of glycoproteins, believed to be encoded by three distinct genes, ZP1/ZPB, ZP2/ZPA, and ZP3/ZPC. We have now determined that the true human orthologue of the mouse Zp1 gene is not ZPB, but that there is a distinct human ZP1 gene. Comparison of the human ZP1 and murine Zp1 genes indicates significant conservation of nucleotide and amino acid sequences, of intron-exon size and organisation, and of regulatory sequences. In addition, the mouse and human ZP1 genes are in a region of conserved synteny between human chromosome 11 and mouse chromosome 19.
| Original language | English |
|---|---|
| Pages (from-to) | 303-6 |
| Number of pages | 4 |
| Journal | BBA - General Subjects |
| Volume | 1447 |
| Issue number | 2-3 |
| DOIs | |
| Publication status | Published - 28 Oct 1999 |
Keywords
- Animals
- Base Sequence
- Chromosome Mapping
- Chromosomes, Human, Pair 11
- Egg Proteins/genetics
- Female
- Humans
- Membrane Glycoproteins/genetics
- Mice
- Molecular Sequence Data
- Receptors, Cell Surface
- Sequence Alignment
- Sequence Analysis, DNA
- Zona Pellucida/metabolism
- Zona Pellucida Glycoproteins
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