Identification of translational dermatology research priorities in the U.K.

Results of an electronic Delphi exercise

E. Healy (Lead / Corresponding author), S. J. Brown, S. M. Langan, S. G. Nicholls, K. Shams, N. J. Reynolds (Lead / Corresponding author)

    Research output: Contribution to journalArticle

    6 Citations (Scopus)
    69 Downloads (Pure)

    Abstract

    Background: Translational research is the direct application of basic and applied research to patient care. It is estimated that there are at least 2000 different skin diseases; thus, there are considerable challenges in seeking to undertake research on each of these disorders. Objectives: This electronic Delphi (e-Delphi) exercise was conducted in order to generate a list of translational dermatology research questions that are regarded as a priority for further investigations. Methods: During the first phase of the e-Delphi exercise, 228 research questions were generated by an expert panel that included clinical academic dermatologists, clinical dermatologists, nonclinical scientists, dermatology trainees and representatives from patient support groups. Results: Following completion of the second and third phases, 40 questions on inflammatory skin disease, 20 questions on structural skin disorders/genodermatoses, 37 questions on skin cancer and eight miscellaneous questions were designated as priority translational dermatology research questions (PRQs). In addition to PRQs on a variety of disease areas (including multiple PRQs on psoriasis, eczema, squamous cell carcinoma and melanoma), there were a number of cross-cutting themes that identified a need to investigate mechanisms/pathogenesis of disease and the necessity to improve treatments for patients with skin disease. Conclusions: It is predicted that this list of PRQs will help to provide a strategic direction for translational dermatology research in the U.K. and that addressing this list of questions will ultimately provide clinical benefit for substantial numbers of patients with skin disorders.

    Original languageEnglish
    Pages (from-to)1191-1198
    Number of pages8
    JournalBritish Journal of Dermatology
    Volume173
    Issue number5
    Early online date6 Jul 2015
    DOIs
    Publication statusPublished - 14 Oct 2015

    Fingerprint

    Translational Medical Research
    Dermatology
    Exercise
    Research
    Skin Diseases
    Patient Advocacy
    Skin
    Self-Help Groups
    Eczema
    Skin Neoplasms
    Psoriasis
    Squamous Cell Carcinoma
    Melanoma
    Patient Care

    Cite this

    Healy, E. ; Brown, S. J. ; Langan, S. M. ; Nicholls, S. G. ; Shams, K. ; Reynolds, N. J. / Identification of translational dermatology research priorities in the U.K. Results of an electronic Delphi exercise. In: British Journal of Dermatology. 2015 ; Vol. 173, No. 5. pp. 1191-1198.
    @article{b0166a53b73d408fb17ad824a26022e2,
    title = "Identification of translational dermatology research priorities in the U.K.: Results of an electronic Delphi exercise",
    abstract = "Background: Translational research is the direct application of basic and applied research to patient care. It is estimated that there are at least 2000 different skin diseases; thus, there are considerable challenges in seeking to undertake research on each of these disorders. Objectives: This electronic Delphi (e-Delphi) exercise was conducted in order to generate a list of translational dermatology research questions that are regarded as a priority for further investigations. Methods: During the first phase of the e-Delphi exercise, 228 research questions were generated by an expert panel that included clinical academic dermatologists, clinical dermatologists, nonclinical scientists, dermatology trainees and representatives from patient support groups. Results: Following completion of the second and third phases, 40 questions on inflammatory skin disease, 20 questions on structural skin disorders/genodermatoses, 37 questions on skin cancer and eight miscellaneous questions were designated as priority translational dermatology research questions (PRQs). In addition to PRQs on a variety of disease areas (including multiple PRQs on psoriasis, eczema, squamous cell carcinoma and melanoma), there were a number of cross-cutting themes that identified a need to investigate mechanisms/pathogenesis of disease and the necessity to improve treatments for patients with skin disease. Conclusions: It is predicted that this list of PRQs will help to provide a strategic direction for translational dermatology research in the U.K. and that addressing this list of questions will ultimately provide clinical benefit for substantial numbers of patients with skin disorders.",
    author = "E. Healy and Brown, {S. J.} and Langan, {S. M.} and Nicholls, {S. G.} and K. Shams and Reynolds, {N. J.}",
    note = "Funded by: British Association of Dermatologists, Wellcome Trust Intermediate Clinical Fellowship (Grant Number: WT086398MA), National Institute for Health Research Clinician Scientist Fellowship, Canadian Institutes of Health Research Postdoctoral Fellowship( Grant Number: 122403), Wellcome Trust Clinical Research Fellow (Grant Number: WT100119/Z/12/Z).",
    year = "2015",
    month = "10",
    day = "14",
    doi = "10.1111/bjd.14022",
    language = "English",
    volume = "173",
    pages = "1191--1198",
    journal = "British Journal of Dermatology",
    issn = "0007-0963",
    publisher = "Wiley",
    number = "5",

    }

    Identification of translational dermatology research priorities in the U.K. Results of an electronic Delphi exercise. / Healy, E. (Lead / Corresponding author); Brown, S. J.; Langan, S. M.; Nicholls, S. G.; Shams, K.; Reynolds, N. J. (Lead / Corresponding author).

    In: British Journal of Dermatology, Vol. 173, No. 5, 14.10.2015, p. 1191-1198.

    Research output: Contribution to journalArticle

    TY - JOUR

    T1 - Identification of translational dermatology research priorities in the U.K.

    T2 - Results of an electronic Delphi exercise

    AU - Healy, E.

    AU - Brown, S. J.

    AU - Langan, S. M.

    AU - Nicholls, S. G.

    AU - Shams, K.

    AU - Reynolds, N. J.

    N1 - Funded by: British Association of Dermatologists, Wellcome Trust Intermediate Clinical Fellowship (Grant Number: WT086398MA), National Institute for Health Research Clinician Scientist Fellowship, Canadian Institutes of Health Research Postdoctoral Fellowship( Grant Number: 122403), Wellcome Trust Clinical Research Fellow (Grant Number: WT100119/Z/12/Z).

    PY - 2015/10/14

    Y1 - 2015/10/14

    N2 - Background: Translational research is the direct application of basic and applied research to patient care. It is estimated that there are at least 2000 different skin diseases; thus, there are considerable challenges in seeking to undertake research on each of these disorders. Objectives: This electronic Delphi (e-Delphi) exercise was conducted in order to generate a list of translational dermatology research questions that are regarded as a priority for further investigations. Methods: During the first phase of the e-Delphi exercise, 228 research questions were generated by an expert panel that included clinical academic dermatologists, clinical dermatologists, nonclinical scientists, dermatology trainees and representatives from patient support groups. Results: Following completion of the second and third phases, 40 questions on inflammatory skin disease, 20 questions on structural skin disorders/genodermatoses, 37 questions on skin cancer and eight miscellaneous questions were designated as priority translational dermatology research questions (PRQs). In addition to PRQs on a variety of disease areas (including multiple PRQs on psoriasis, eczema, squamous cell carcinoma and melanoma), there were a number of cross-cutting themes that identified a need to investigate mechanisms/pathogenesis of disease and the necessity to improve treatments for patients with skin disease. Conclusions: It is predicted that this list of PRQs will help to provide a strategic direction for translational dermatology research in the U.K. and that addressing this list of questions will ultimately provide clinical benefit for substantial numbers of patients with skin disorders.

    AB - Background: Translational research is the direct application of basic and applied research to patient care. It is estimated that there are at least 2000 different skin diseases; thus, there are considerable challenges in seeking to undertake research on each of these disorders. Objectives: This electronic Delphi (e-Delphi) exercise was conducted in order to generate a list of translational dermatology research questions that are regarded as a priority for further investigations. Methods: During the first phase of the e-Delphi exercise, 228 research questions were generated by an expert panel that included clinical academic dermatologists, clinical dermatologists, nonclinical scientists, dermatology trainees and representatives from patient support groups. Results: Following completion of the second and third phases, 40 questions on inflammatory skin disease, 20 questions on structural skin disorders/genodermatoses, 37 questions on skin cancer and eight miscellaneous questions were designated as priority translational dermatology research questions (PRQs). In addition to PRQs on a variety of disease areas (including multiple PRQs on psoriasis, eczema, squamous cell carcinoma and melanoma), there were a number of cross-cutting themes that identified a need to investigate mechanisms/pathogenesis of disease and the necessity to improve treatments for patients with skin disease. Conclusions: It is predicted that this list of PRQs will help to provide a strategic direction for translational dermatology research in the U.K. and that addressing this list of questions will ultimately provide clinical benefit for substantial numbers of patients with skin disorders.

    UR - http://www.scopus.com/inward/record.url?scp=84952034758&partnerID=8YFLogxK

    U2 - 10.1111/bjd.14022

    DO - 10.1111/bjd.14022

    M3 - Article

    VL - 173

    SP - 1191

    EP - 1198

    JO - British Journal of Dermatology

    JF - British Journal of Dermatology

    SN - 0007-0963

    IS - 5

    ER -