Identification of translational dermatology research priorities in the U.K. Results of an electronic Delphi exercise

TY - JOUR

T1 - Identification of translational dermatology research priorities in the U.K.

T2 - Results of an electronic Delphi exercise

AU - Healy, E.

AU - Brown, S. J.

AU - Langan, S. M.

AU - Nicholls, S. G.

AU - Shams, K.

AU - Reynolds, N. J.

N1 - Funded by: British Association of Dermatologists, Wellcome Trust Intermediate Clinical Fellowship (Grant Number: WT086398MA), National Institute for Health Research Clinician Scientist Fellowship, Canadian Institutes of Health Research Postdoctoral Fellowship( Grant Number: 122403), Wellcome Trust Clinical Research Fellow (Grant Number: WT100119/Z/12/Z).

PY - 2015/10/14

Y1 - 2015/10/14

N2 - Background: Translational research is the direct application of basic and applied research to patient care. It is estimated that there are at least 2000 different skin diseases; thus, there are considerable challenges in seeking to undertake research on each of these disorders. Objectives: This electronic Delphi (e-Delphi) exercise was conducted in order to generate a list of translational dermatology research questions that are regarded as a priority for further investigations. Methods: During the first phase of the e-Delphi exercise, 228 research questions were generated by an expert panel that included clinical academic dermatologists, clinical dermatologists, nonclinical scientists, dermatology trainees and representatives from patient support groups. Results: Following completion of the second and third phases, 40 questions on inflammatory skin disease, 20 questions on structural skin disorders/genodermatoses, 37 questions on skin cancer and eight miscellaneous questions were designated as priority translational dermatology research questions (PRQs). In addition to PRQs on a variety of disease areas (including multiple PRQs on psoriasis, eczema, squamous cell carcinoma and melanoma), there were a number of cross-cutting themes that identified a need to investigate mechanisms/pathogenesis of disease and the necessity to improve treatments for patients with skin disease. Conclusions: It is predicted that this list of PRQs will help to provide a strategic direction for translational dermatology research in the U.K. and that addressing this list of questions will ultimately provide clinical benefit for substantial numbers of patients with skin disorders.

AB - Background: Translational research is the direct application of basic and applied research to patient care. It is estimated that there are at least 2000 different skin diseases; thus, there are considerable challenges in seeking to undertake research on each of these disorders. Objectives: This electronic Delphi (e-Delphi) exercise was conducted in order to generate a list of translational dermatology research questions that are regarded as a priority for further investigations. Methods: During the first phase of the e-Delphi exercise, 228 research questions were generated by an expert panel that included clinical academic dermatologists, clinical dermatologists, nonclinical scientists, dermatology trainees and representatives from patient support groups. Results: Following completion of the second and third phases, 40 questions on inflammatory skin disease, 20 questions on structural skin disorders/genodermatoses, 37 questions on skin cancer and eight miscellaneous questions were designated as priority translational dermatology research questions (PRQs). In addition to PRQs on a variety of disease areas (including multiple PRQs on psoriasis, eczema, squamous cell carcinoma and melanoma), there were a number of cross-cutting themes that identified a need to investigate mechanisms/pathogenesis of disease and the necessity to improve treatments for patients with skin disease. Conclusions: It is predicted that this list of PRQs will help to provide a strategic direction for translational dermatology research in the U.K. and that addressing this list of questions will ultimately provide clinical benefit for substantial numbers of patients with skin disorders.

UR - https://www.scopus.com/pages/publications/84983095482

U2 - 10.1111/bjd.14022

DO - 10.1111/bjd.14022

M3 - Article

C2 - 26149834

SN - 0007-0963

VL - 173

SP - 1191

EP - 1198

JO - British Journal of Dermatology

JF - British Journal of Dermatology

IS - 5

ER -