Identifying optimal prostate biopsy strategy for the detection rate of clinically significant prostate cancer: A Systematic Re-view and Meta-Analysis of Randomised Controlled Trials (RCTs) in Biopsy-Naïve Population

Wafa Aloufi (Lead / Corresponding author), Abdulrahman Al Mopti, Anas Al Taweel, Zhihong Huang, Ghulam Nabi

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Abstract

Background: The growing role of multiparametric MRI (mpMRI) and MRI-targeted bi-opsy (MRI-TBx) suggests they may replace random systematic biopsy (SBx), specifically detection and subsequent treatment of clinically significant prostate cancer (csPCa). Objectives: To perform a systematic review and meta-analysis of randomised controlled trials (RCTs) comparing the detec-tion rates (DR) of csPCa using MRI-TBx alone, SBx alone, or their combination in biopsy naïve pa-tients suspected of having prostate cancer (PCa). Methods: PubMed, MEDLINE, Embase, and the Cochrane Library were searched up to March 23, 2023, for RCTs comparing PCa DR between biopsy strategies in patients with suspected prostate cancer. Detection rates were pooled using ran-dom/fixed effect models and the study quality was assessed using the Cochrane risk of bias revised tool. Results: Ten RCTs (involving 3646 patients) were analysed revealing that the combined biopsy method achieved higher overall and csPCa DR compared to the SBx method alone (RR=1.40 [95% CI =1.15–1.71]and 1.47 [95% CI = 1.13–1.92], respectively). However, there was no significant differ-ence in DR for clinically insignificant prostate cancer (ciPCa) between the two methods. Conclusions: This review concludes that MRI-TBx and SBx detect overall and clinically significant prostate cancer (csPCa) better than SBx alone. The variety of factors requires cautious interpretation, yet these findings are the strongest evidence. The combination technique is recommended for biopsy-naïve groups, but more study is needed to optimise execution and overcome uncertainties.
Original languageEnglish
Article number458
Number of pages13
JournalCancers
Volume17
Issue number3
DOIs
Publication statusPublished - 29 Jan 2025

Keywords

  • Prostate cancer
  • Image guided biopsy
  • Ultrasound
  • MRI
  • Prostate cancer sampling
  • Random systematic biopsy
  • Meta-analysis

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