In vivo gene silencing following non-invasive siRNA delivery into the skin using a novel topical formulation

Search results

• Finished

  Keratinizing Skin Disorder: From Systems Biology to Targeted Therapeutics (New Investigator Award)

  Leslie Pedrioli, D. (Investigator)

  Medical Research Council

  1/07/14 → 30/06/17

  Project: Research

  • Fuchs Endothelial Corneal Dystrophy 100%
  • Missense Mutation 83%
  • KRT12 76%
  • In Vivo Gene Silencing 66%
  • Topical Formulation 66%

• Dermatology and Genetic Medicine (Strategic Grant) (Joint with Kings College London)

  Barton, G. (Investigator), Campbell, P. (Investigator), Hickerson, R. (Investigator), Leigh, I. (Investigator), McLean, I. (Investigator) & Wyatt, P. (Investigator)

  1/08/12 → 30/04/19

  Project: Research

  • Atopic Dermatitis 100%
  • Palmoplantar Keratoderma 38%
  • Gain-of-function mutation 33%
  • Filaggrin 32%
  • Disease 29%