IL-1 family in breast cancer: potential interplay with leptin and other adipocytokines

Stéphane Perrier, Florence Caldefie-Chézet, Marie-Paule Vasson

    Research output: Contribution to journalArticlepeer-review

    62 Citations (Scopus)

    Abstract

    Obesity is associated with an increased risk of breast cancer. interleukin-1 (IL-1), a pro-inflammatory cytokine secreted by adipose tissue, is involved in breast cancer development. There is also convincing evidence that other adipocytokines including leptin not only have a role in haematopoiesis, reproduction and immunity but are also growth factors in cancer. Therefore, IL-1 family and leptin family are adipocytokines which could represent a major link between obesity and breast cancer progression. This minireview provides insight into recent findings on the prognostic significance of IL-1 and leptin in mammary tumours, and discusses the potential interplay between IL-1 family members and adipocyte-derived hormones in breast cancer.
    Original languageEnglish
    Pages (from-to)259-265
    Number of pages7
    JournalFEBS Letters
    Volume583
    Issue number2
    DOIs
    Publication statusPublished - 22 Jan 2009

    Keywords

    • Adipokines
    • Breast Neoplasms
    • Female
    • Humans
    • Interleukin-1
    • Leptin
    • Obesity

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