IL-1 family in breast cancer: potential interplay with leptin and other adipocytokines

Stéphane Perrier; Florence Caldefie-Chézet; Marie-Paule Vasson

doi:10.1016/j.febslet.2008.12.030

IL-1 family in breast cancer: potential interplay with leptin and other adipocytokines

Stéphane Perrier
, Florence Caldefie-Chézet
, Marie-Paule Vasson

Research output: Contribution to journal › Article › peer-review

77 Citations (Scopus)

Abstract

Obesity is associated with an increased risk of breast cancer. interleukin-1 (IL-1), a pro-inflammatory cytokine secreted by adipose tissue, is involved in breast cancer development. There is also convincing evidence that other adipocytokines including leptin not only have a role in haematopoiesis, reproduction and immunity but are also growth factors in cancer. Therefore, IL-1 family and leptin family are adipocytokines which could represent a major link between obesity and breast cancer progression. This minireview provides insight into recent findings on the prognostic significance of IL-1 and leptin in mammary tumours, and discusses the potential interplay between IL-1 family members and adipocyte-derived hormones in breast cancer.

Original language	English
Pages (from-to)	259-265
Number of pages	7
Journal	FEBS Letters
Volume	583
Issue number	2
DOIs	https://doi.org/10.1016/j.febslet.2008.12.030
Publication status	Published - 22 Jan 2009

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Adipokines
Breast Neoplasms
Female
Humans
Interleukin-1
Leptin
Obesity

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10.1016/j.febslet.2008.12.030

http://www.journals.elsevier.com/febs-letters

Cite this

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title = "IL-1 family in breast cancer: potential interplay with leptin and other adipocytokines",

abstract = "Obesity is associated with an increased risk of breast cancer. interleukin-1 (IL-1), a pro-inflammatory cytokine secreted by adipose tissue, is involved in breast cancer development. There is also convincing evidence that other adipocytokines including leptin not only have a role in haematopoiesis, reproduction and immunity but are also growth factors in cancer. Therefore, IL-1 family and leptin family are adipocytokines which could represent a major link between obesity and breast cancer progression. This minireview provides insight into recent findings on the prognostic significance of IL-1 and leptin in mammary tumours, and discusses the potential interplay between IL-1 family members and adipocyte-derived hormones in breast cancer.",

keywords = "Adipokines, Breast Neoplasms, Female, Humans, Interleukin-1, Leptin, Obesity",

author = "St{\'e}phane Perrier and Florence Caldefie-Ch{\'e}zet and Marie-Paule Vasson",

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doi = "10.1016/j.febslet.2008.12.030",

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TY - JOUR

T1 - IL-1 family in breast cancer

T2 - potential interplay with leptin and other adipocytokines

AU - Perrier, Stéphane

AU - Caldefie-Chézet, Florence

AU - Vasson, Marie-Paule

PY - 2009/1/22

Y1 - 2009/1/22

N2 - Obesity is associated with an increased risk of breast cancer. interleukin-1 (IL-1), a pro-inflammatory cytokine secreted by adipose tissue, is involved in breast cancer development. There is also convincing evidence that other adipocytokines including leptin not only have a role in haematopoiesis, reproduction and immunity but are also growth factors in cancer. Therefore, IL-1 family and leptin family are adipocytokines which could represent a major link between obesity and breast cancer progression. This minireview provides insight into recent findings on the prognostic significance of IL-1 and leptin in mammary tumours, and discusses the potential interplay between IL-1 family members and adipocyte-derived hormones in breast cancer.

AB - Obesity is associated with an increased risk of breast cancer. interleukin-1 (IL-1), a pro-inflammatory cytokine secreted by adipose tissue, is involved in breast cancer development. There is also convincing evidence that other adipocytokines including leptin not only have a role in haematopoiesis, reproduction and immunity but are also growth factors in cancer. Therefore, IL-1 family and leptin family are adipocytokines which could represent a major link between obesity and breast cancer progression. This minireview provides insight into recent findings on the prognostic significance of IL-1 and leptin in mammary tumours, and discusses the potential interplay between IL-1 family members and adipocyte-derived hormones in breast cancer.

KW - Adipokines

KW - Breast Neoplasms

KW - Female

KW - Humans

KW - Interleukin-1

KW - Leptin

KW - Obesity

U2 - 10.1016/j.febslet.2008.12.030

DO - 10.1016/j.febslet.2008.12.030

M3 - Article

C2 - 19111549

SN - 0014-5793

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SP - 259

EP - 265

JO - FEBS Letters

JF - FEBS Letters

IS - 2

ER -

IL-1 family in breast cancer: potential interplay with leptin and other adipocytokines

Abstract

UN SDGs

Keywords

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