IL-33: a central cytokine in helminth infections

Henry J. McSorley; Danielle J. Smyth

doi:10.1016/j.smim.2021.101532

IL-33: a central cytokine in helminth infections

Henry J. McSorley (Lead / Corresponding author), Danielle J. Smyth

Cell Signalling and Immunology

Research output: Contribution to journal › Review article › peer-review

24 Citations (Scopus)

226 Downloads (Pure)

Abstract

IL-33 is an alarmin cytokine which has been implicated in allergy, fibrosis, inflammation, tumorigenesis, metabolism, and homeostasis. However, amongst its strongest roles are in helminth infections, where IL-33 usually (but not always) is central to induction of an effective anti-parasitic immune response. In this review, we will summarise the literature around this fascinating cytokine, its activity on immune and non-immune cells, the unique (and sometimes counterintuitive) responses it induces, and how it can coordinate the immune response during infections by parasitic helminths. Finally, we will summarise some of the ways that parasites have developed to modulate the IL-33 pathway for their own benefit.

Original language	English
Article number	101532
Number of pages	12
Journal	Seminars in Immunology
Volume	53
DOIs	https://doi.org/10.1016/j.smim.2021.101532
Publication status	Published - 22 Nov 2021

Keywords

Helminth
IL-33
Immunoregulation
Parasite

ASJC Scopus subject areas

Immunology and Allergy
Immunology

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10.1016/j.smim.2021.101532Licence: Elsevier User Licence

Author Accepted ManuscriptAccepted author manuscript, 928 KBLicence: CC BY-NC-ND

Cite this

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title = "IL-33: a central cytokine in helminth infections",

abstract = "IL-33 is an alarmin cytokine which has been implicated in allergy, fibrosis, inflammation, tumorigenesis, metabolism, and homeostasis. However, amongst its strongest roles are in helminth infections, where IL-33 usually (but not always) is central to induction of an effective anti-parasitic immune response. In this review, we will summarise the literature around this fascinating cytokine, its activity on immune and non-immune cells, the unique (and sometimes counterintuitive) responses it induces, and how it can coordinate the immune response during infections by parasitic helminths. Finally, we will summarise some of the ways that parasites have developed to modulate the IL-33 pathway for their own benefit. ",

keywords = "Helminth, IL-33, Immunoregulation, Parasite",

author = "McSorley, {Henry J.} and Smyth, {Danielle J.}",

note = "This work was supported by LONGFONDS. Accelerate as part of the AWWA project, the Medical Research Council (MR/S000593/1) and a Wellcome Investigator award (221914/Z/20/Z).",

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T2 - a central cytokine in helminth infections

AU - McSorley, Henry J.

AU - Smyth, Danielle J.

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PY - 2021/11/22

Y1 - 2021/11/22

N2 - IL-33 is an alarmin cytokine which has been implicated in allergy, fibrosis, inflammation, tumorigenesis, metabolism, and homeostasis. However, amongst its strongest roles are in helminth infections, where IL-33 usually (but not always) is central to induction of an effective anti-parasitic immune response. In this review, we will summarise the literature around this fascinating cytokine, its activity on immune and non-immune cells, the unique (and sometimes counterintuitive) responses it induces, and how it can coordinate the immune response during infections by parasitic helminths. Finally, we will summarise some of the ways that parasites have developed to modulate the IL-33 pathway for their own benefit.

AB - IL-33 is an alarmin cytokine which has been implicated in allergy, fibrosis, inflammation, tumorigenesis, metabolism, and homeostasis. However, amongst its strongest roles are in helminth infections, where IL-33 usually (but not always) is central to induction of an effective anti-parasitic immune response. In this review, we will summarise the literature around this fascinating cytokine, its activity on immune and non-immune cells, the unique (and sometimes counterintuitive) responses it induces, and how it can coordinate the immune response during infections by parasitic helminths. Finally, we will summarise some of the ways that parasites have developed to modulate the IL-33 pathway for their own benefit.

KW - Helminth

KW - IL-33

KW - Immunoregulation

KW - Parasite

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U2 - 10.1016/j.smim.2021.101532

DO - 10.1016/j.smim.2021.101532

M3 - Review article

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VL - 53

JO - Seminars in Immunology

JF - Seminars in Immunology

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ER -

IL-33: a central cytokine in helminth infections

Abstract

Keywords

ASJC Scopus subject areas

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Other files and links

Fingerprint

Molecular Regulators of the Alarmin IL-33 in Health and Disease

MICA: Modulation of IL-33-dependent Responses Using Parasite Products (Transfer)

Cite this

IL-33: a central cytokine in helminth infections

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Projects

Molecular Regulators of the Alarmin IL-33 in Health and Disease

MICA: Modulation of IL-33-dependent Responses Using Parasite Products (Transfer)

Cite this