Projects per year
Abstract
HpARI is an immunomodulatory protein secreted by the intestinal nematode Heligmosomoides polygyrus bakeri, which binds and blocks IL-33. Here, we find that the H. polygyrus bakeri genome contains three HpARI family members and that these have different effects on IL-33-dependent responses in vitro and in vivo, with HpARI1+2 suppressing and HpARI3 amplifying these responses. All HpARIs have sub-nanomolar affinity for mouse IL-33; however, HpARI3 does not block IL-33-ST2 interactions. Instead, HpARI3 stabilizes IL-33, increasing the half-life of the cytokine and amplifying responses to it in vivo. Together, these data show that H. polygyrus bakeri secretes a family of HpARI proteins with both overlapping and distinct functions, comprising a complex immunomodulatory arsenal of host-targeted proteins.
Original language | English |
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Article number | e00395-23 |
Journal | Infection and Immunity |
Volume | 92 |
Issue number | 3 |
Early online date | 31 Jan 2024 |
DOIs | |
Publication status | Published - Mar 2024 |
Keywords
- IL-33
- helminth
- immunomodulation
Fingerprint
Dive into the research topics of 'IL-33-binding HpARI family homologues with divergent effects in suppressing or enhancing type 2 immune responses'. Together they form a unique fingerprint.-
Molecular Regulators of the Alarmin IL-33 in Health and Disease
McSorley, H. (Investigator)
1/07/21 → 30/06/26
Project: Research
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MICA: Modulation of IL-33-dependent Responses Using Parasite Products (Transfer)
McSorley, H. (Investigator)
1/02/20 → 30/06/22
Project: Research
Equipment
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Fingerprints Proteomics Facility
Centre for Advanced Scientific TechnologiesFacility/equipment: Facility