Image-Guided High-Intensity Focused Ultrasound, A Novel Application for Interventional Nuclear Medicine?

Xinrui Zhang, Lisa Landgraf, Nikolaos Bailis, Michael Unger, Thies H. Jochimsen, Andreas Melzer (Lead / Corresponding author)

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)
143 Downloads (Pure)


Image-guided high-intensity focused ultrasound (HIFU) has been increasingly used in medicine over the past few decades, and several systems for such have become commercially available. HIFU has passed regulatory approval around the world for the ablation of various solid tumors, the treatment of neurologic diseases, and the palliative management of bone metastases. The mechanical and thermal effects of focused ultrasound provide a possibility for histotripsy, supportive radiation therapy, and targeted drug delivery. The integration of imaging modalities into HIFU systems allowsfor precise temperature monitoring and accurate treatment planning, increasing the safety and efficiency of treatment. Preclinical and clinical results have demonstrated the potential of image-guided HIFU to reduce adverse effects and increase the quality of life postoperatively. Interventional nuclear image–guided HIFU is an attractive noninvasive option for the future.
Original languageEnglish
Pages (from-to)1181-1188
Number of pages8
JournalJournal of Nuclear Medicine
Issue number9
Early online date4 Jun 2021
Publication statusPublished - 1 Sept 2021


  • PET/MR image guidance
  • hyperthermia
  • image-guided HIFU
  • targeted drug delivery
  • tumor ablation

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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