IMI European Lead Factory - democratizing access to high-throughput screening

Philip S Jones; Sylviane Boucharens; Stuart P McElroy; Angus Morrison; Saman Honarnejad; Stan van Boeckel; Helma van den Hurk; Daniel Basting; Jörg Hüser; Stefan Jaroch; Eckhard Ottow; Jorg Benningshof; Rutger H. A. Folmer; Frank Leemhuis; Patricia M. Kramer-Verhulst; Vera J. M. Nies; Kristina M. Orrling; Ton Rijnders; Claudia Pfander; Ola Engkvist; Garry Pairaudeau; Peter B. Simpson; Jean-Yves Ortholand; Didier Roche; Alexander Dömling; Sven M Kühnert; Peter W. M. Roevens; Herman van Vlijmen; Eva J A van Wanrooij; Christophe Verbruggen; Peter Nussbaumer; Huib Ovaa; Mario van der Stelt; Klaus Baek Simonsen; Lena Tagmose; Herbert Waldmann; James Duffy; Dirk Finsinger; Mirek Jurzak; Nicola A Burgess-Brown; Wen H. Lee; Floris P J T Rutjes; Hubert Haag; Christopher Kallus; Hartmut Mors; Thierry Dorval; Brigitte Lesur; Fernando Ramon Olayo; Daniel Hamza; Geraint Jones; Christopher Pearce; Alexander Piechot; Dimitrios Tzalis; Mads H. Clausen; Jeremy Davis; Daphné Derouane; Céline Vermeiren; Markus Kaiser; Robert A. Stockman; Denise V. Barrault; Andrew D. Pannifer; Jason R Swedlow; Adam S. Nelson; Romano V. A. Orru; Eelco Ruijter; Steven P. van Helden; Volkhart M. Li; Ton Vries; Jon S. B. de Vlieger

doi:10.1038/d41573-021-00196-3

IMI European Lead Factory - democratizing access to high-throughput screening

Philip S Jones, Sylviane Boucharens, Stuart P McElroy, Angus Morrison, Saman Honarnejad, Stan van Boeckel, Helma van den Hurk, Daniel Basting, Jörg Hüser, Stefan Jaroch, Eckhard Ottow, Jorg Benningshof, Rutger H. A. Folmer, Frank Leemhuis, Patricia M. Kramer-Verhulst, Vera J. M. Nies, Kristina M. Orrling, Ton Rijnders, Claudia Pfander, Ola EngkvistGarry Pairaudeau, Peter B. Simpson, Jean-Yves Ortholand, Didier Roche, Alexander Dömling, Sven M Kühnert, Peter W. M. Roevens, Herman van Vlijmen, Eva J A van Wanrooij, Christophe Verbruggen, Peter Nussbaumer, Huib Ovaa, Mario van der Stelt, Klaus Baek Simonsen, Lena Tagmose, Herbert Waldmann, James Duffy, Dirk Finsinger, Mirek Jurzak, Nicola A Burgess-Brown, Wen H. Lee, Floris P J T Rutjes, Hubert Haag, Christopher Kallus, Hartmut Mors, Thierry Dorval, Brigitte Lesur, Fernando Ramon Olayo, Daniel Hamza, Geraint Jones, Christopher Pearce, Alexander Piechot, Dimitrios Tzalis, Mads H. Clausen, Jeremy Davis, Daphné Derouane, Céline Vermeiren, Markus Kaiser, Robert A. Stockman, Denise V. Barrault, Andrew D. Pannifer, Jason R Swedlow, Adam S. Nelson, Romano V. A. Orru, Eelco Ruijter, Steven P. van Helden, Volkhart M. Li, Ton Vries, Jon S. B. de Vlieger

Research output: Contribution to journal › Comment/debate › peer-review

Original language	English
Pages (from-to)	245-246
Number of pages	2
Journal	Nature reviews. Drug discovery
Volume	21
Early online date	14 Dec 2021
DOIs	https://doi.org/10.1038/d41573-021-00196-3
Publication status	Published - Apr 2022

Keywords

Drug Discovery
High-Throughput Screening Assays
Humans
Small Molecule Libraries

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10.1038/d41573-021-00196-3

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Jones, P. S., Boucharens, S., McElroy, S. P., Morrison, A., Honarnejad, S., van Boeckel, S., van den Hurk, H., Basting, D., Hüser, J., Jaroch, S., Ottow, E., Benningshof, J., Folmer, R. H. A., Leemhuis, F., Kramer-Verhulst, P. M., Nies, V. J. M., Orrling, K. M., Rijnders, T., Pfander, C., ... de Vlieger, J. S. B. (2022). IMI European Lead Factory - democratizing access to high-throughput screening. Nature reviews. Drug discovery, 21, 245-246. https://doi.org/10.1038/d41573-021-00196-3

@article{2f6abc88449d4cefa8b462b54c76e1a3,

title = "IMI European Lead Factory - democratizing access to high-throughput screening",

keywords = "Drug Discovery, High-Throughput Screening Assays, Humans, Small Molecule Libraries",

author = "Jones, {Philip S} and Sylviane Boucharens and McElroy, {Stuart P} and Angus Morrison and Saman Honarnejad and {van Boeckel}, Stan and {van den Hurk}, Helma and Daniel Basting and J{\"o}rg H{\"u}ser and Stefan Jaroch and Eckhard Ottow and Jorg Benningshof and Folmer, {Rutger H. A.} and Frank Leemhuis and Kramer-Verhulst, {Patricia M.} and Nies, {Vera J. M.} and Orrling, {Kristina M.} and Ton Rijnders and Claudia Pfander and Ola Engkvist and Garry Pairaudeau and Simpson, {Peter B.} and Jean-Yves Ortholand and Didier Roche and Alexander D{\"o}mling and K{\"u}hnert, {Sven M} and Roevens, {Peter W. M.} and {van Vlijmen}, Herman and {van Wanrooij}, {Eva J A} and Christophe Verbruggen and Peter Nussbaumer and Huib Ovaa and {van der Stelt}, Mario and Simonsen, {Klaus Baek} and Lena Tagmose and Herbert Waldmann and James Duffy and Dirk Finsinger and Mirek Jurzak and Burgess-Brown, {Nicola A} and Lee, {Wen H.} and Rutjes, {Floris P J T} and Hubert Haag and Christopher Kallus and Hartmut Mors and Thierry Dorval and Brigitte Lesur and {Ramon Olayo}, Fernando and Daniel Hamza and Geraint Jones and Christopher Pearce and Alexander Piechot and Dimitrios Tzalis and Clausen, {Mads H.} and Jeremy Davis and Daphn{\'e} Derouane and C{\'e}line Vermeiren and Markus Kaiser and Stockman, {Robert A.} and Barrault, {Denise V.} and Pannifer, {Andrew D.} and Swedlow, {Jason R} and Nelson, {Adam S.} and Orru, {Romano V. A.} and Eelco Ruijter and {van Helden}, {Steven P.} and Li, {Volkhart M.} and Ton Vries and {de Vlieger}, {Jon S. B.}",

note = "The European Lead Factory has received support from the Innovative Medicines Initiative (IMI) Joint Undertaking under grant agreement no.115489, resources of which are composed of financial contribution from the EU{\textquoteright}s Seventh Framework Programme and EFPIA companies{\textquoteright} in-kind contribution. This project has also received funding from the IMI-2 Joint Undertaking (JU) under grant agreement no. 806948. The JU receives support from the EU{\textquoteright}s Horizon 2020 research and innovation programme, the EFPIA and Medicines for Malaria Venture (MMV).",

year = "2022",

month = apr,

doi = "10.1038/d41573-021-00196-3",

language = "English",

volume = "21",

pages = "245--246",

journal = "Nature Reviews Drug Discovery",

issn = "1474-1776",

publisher = "Nature Publishing Group",

}

Jones, PS, Boucharens, S, McElroy, SP, Morrison, A, Honarnejad, S, van Boeckel, S, van den Hurk, H, Basting, D, Hüser, J, Jaroch, S, Ottow, E, Benningshof, J, Folmer, RHA, Leemhuis, F, Kramer-Verhulst, PM, Nies, VJM, Orrling, KM, Rijnders, T, Pfander, C, Engkvist, O, Pairaudeau, G, Simpson, PB, Ortholand, J-Y, Roche, D, Dömling, A, Kühnert, SM, Roevens, PWM, van Vlijmen, H, van Wanrooij, EJA, Verbruggen, C, Nussbaumer, P, Ovaa, H, van der Stelt, M, Simonsen, KB, Tagmose, L, Waldmann, H, Duffy, J, Finsinger, D, Jurzak, M, Burgess-Brown, NA, Lee, WH, Rutjes, FPJT, Haag, H, Kallus, C, Mors, H, Dorval, T, Lesur, B, Ramon Olayo, F, Hamza, D, Jones, G, Pearce, C, Piechot, A, Tzalis, D, Clausen, MH, Davis, J, Derouane, D, Vermeiren, C, Kaiser, M, Stockman, RA, Barrault, DV, Pannifer, AD, Swedlow, JR, Nelson, AS, Orru, RVA, Ruijter, E, van Helden, SP, Li, VM, Vries, T & de Vlieger, JSB 2022, 'IMI European Lead Factory - democratizing access to high-throughput screening', Nature reviews. Drug discovery, vol. 21, pp. 245-246. https://doi.org/10.1038/d41573-021-00196-3

TY - JOUR

T1 - IMI European Lead Factory - democratizing access to high-throughput screening

AU - Jones, Philip S

AU - Boucharens, Sylviane

AU - McElroy, Stuart P

AU - Morrison, Angus

AU - Honarnejad, Saman

AU - van Boeckel, Stan

AU - van den Hurk, Helma

AU - Basting, Daniel

AU - Hüser, Jörg

AU - Jaroch, Stefan

AU - Ottow, Eckhard

AU - Benningshof, Jorg

AU - Folmer, Rutger H. A.

AU - Leemhuis, Frank

AU - Kramer-Verhulst, Patricia M.

AU - Nies, Vera J. M.

AU - Orrling, Kristina M.

AU - Rijnders, Ton

AU - Pfander, Claudia

AU - Engkvist, Ola

AU - Pairaudeau, Garry

AU - Simpson, Peter B.

AU - Ortholand, Jean-Yves

AU - Roche, Didier

AU - Dömling, Alexander

AU - Kühnert, Sven M

AU - Roevens, Peter W. M.

AU - van Vlijmen, Herman

AU - van Wanrooij, Eva J A

AU - Verbruggen, Christophe

AU - Nussbaumer, Peter

AU - Ovaa, Huib

AU - van der Stelt, Mario

AU - Simonsen, Klaus Baek

AU - Tagmose, Lena

AU - Waldmann, Herbert

AU - Duffy, James

AU - Finsinger, Dirk

AU - Jurzak, Mirek

AU - Burgess-Brown, Nicola A

AU - Lee, Wen H.

AU - Rutjes, Floris P J T

AU - Haag, Hubert

AU - Kallus, Christopher

AU - Mors, Hartmut

AU - Dorval, Thierry

AU - Lesur, Brigitte

AU - Ramon Olayo, Fernando

AU - Hamza, Daniel

AU - Jones, Geraint

AU - Pearce, Christopher

AU - Piechot, Alexander

AU - Tzalis, Dimitrios

AU - Clausen, Mads H.

AU - Davis, Jeremy

AU - Derouane, Daphné

AU - Vermeiren, Céline

AU - Kaiser, Markus

AU - Stockman, Robert A.

AU - Barrault, Denise V.

AU - Pannifer, Andrew D.

AU - Swedlow, Jason R

AU - Nelson, Adam S.

AU - Orru, Romano V. A.

AU - Ruijter, Eelco

AU - van Helden, Steven P.

AU - Li, Volkhart M.

AU - Vries, Ton

AU - de Vlieger, Jon S. B.

N1 - The European Lead Factory has received support from the Innovative Medicines Initiative (IMI) Joint Undertaking under grant agreement no.115489, resources of which are composed of financial contribution from the EU’s Seventh Framework Programme and EFPIA companies’ in-kind contribution. This project has also received funding from the IMI-2 Joint Undertaking (JU) under grant agreement no. 806948. The JU receives support from the EU’s Horizon 2020 research and innovation programme, the EFPIA and Medicines for Malaria Venture (MMV).

PY - 2022/4

Y1 - 2022/4

KW - Drug Discovery

KW - High-Throughput Screening Assays

KW - Humans

KW - Small Molecule Libraries

UR - http://www.scopus.com/inward/record.url?scp=85128245130&partnerID=8YFLogxK

U2 - 10.1038/d41573-021-00196-3

DO - 10.1038/d41573-021-00196-3

M3 - Comment/debate

C2 - 34907316

VL - 21

SP - 245

EP - 246

JO - Nature Reviews Drug Discovery

JF - Nature Reviews Drug Discovery

SN - 1474-1776

ER -

IMI European Lead Factory - democratizing access to high-throughput screening

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European Lead Factory EUC2LID (IMI) (Joint with 29 other Partners)

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IMI European Lead Factory - democratizing access to high-throughput screening

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European Lead Factory EUC2LID (IMI) (Joint with 29 other Partners)

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