Imidazopyridine Derivatives as Modulators of TNF Activity

Jonathan Mark Bentley; Daniel Christopher Brookings; Julien Alistair Brown; Thomas Paul Cain; Praful Tulshi Chovatia; Anne Marie Foley; Ellen Olivia Gallimore; Laura Jane Gleave; Alexander Heifetz; Helen Tracey Horsley; Martin Clive Hutchings; Victoria Elizabeth Jackson; James Andrew Johnson; Craig Johnstone; Boris Kroeplien; Fabien Claude Comte; Deborah Leigh; Martin Alexander Lowe; James Madden; John Robert Porter; Joanna Rachel Quincey; Laura Claire Reed; James Thomas Reuberson; Anthony Richardson; Sarah Emily Richardson; Matthew Duncan Selby; Michael Alan Shaw; Zhaoning Zhu

Imidazopyridine Derivatives as Modulators of TNF Activity

Jonathan Mark Bentley (Inventor)
, Daniel Christopher Brookings (Inventor)
, Julien Alistair Brown (Inventor)
, Thomas Paul Cain (Inventor)
, Praful Tulshi Chovatia (Inventor)
, Anne Marie Foley (Inventor)
, Ellen Olivia Gallimore (Inventor)
, Laura Jane Gleave (Inventor)
, Alexander Heifetz (Inventor)
, Helen Tracey Horsley (Inventor)
, Martin Clive Hutchings (Inventor)
, Victoria Elizabeth Jackson (Inventor)
, James Andrew Johnson (Inventor)
, Craig Johnstone (Inventor)
, Boris Kroeplien (Inventor)
, Fabien Claude Comte (Inventor)
, Deborah Leigh (Inventor)
, Martin Alexander Lowe (Inventor)
, James Madden (Inventor)
, John Robert Porter (Inventor)

Joanna Rachel Quincey (Inventor), Laura Claire Reed (Inventor), James Thomas Reuberson (Inventor), Anthony Richardson (Inventor), Sarah Emily Richardson (Inventor), Matthew Duncan Selby (Inventor), Michael Alan Shaw (Inventor), Zhaoning Zhu (Inventor)

Drug Discovery Unit

Research output: Patent

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Abstract

A series of imidazo[l,2-a]pyridine derivatives of formula (I), being potent modulators of human TNFa activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorders; and oncological disorders.

Original language	English
Patent number	WO/2014/009295
IPC	C07D 471/04 2006.1,C07D 471/04 2006.1,A61K 31/437 2006.1,A61P 29/00 2006.1
Priority date	13/07/12
Filing date	5/07/13
Publication status	Published - 16 Jan 2014

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WO 2014/009295 A1Final published version, 21.5 MB

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Bentley, J. M., Brookings, D. C., Brown, J. A., Cain, T. P., Chovatia, P. T., Foley, A. M., Gallimore, E. O., Gleave, L. J., Heifetz, A., Horsley, H. T., Hutchings, M. C., Jackson, V. E., Johnson, J. A., Johnstone, C., Kroeplien, B., Comte, F. C., Leigh, D., Lowe, M. A., Madden, J., ... Zhu, Z. (2014). Imidazopyridine Derivatives as Modulators of TNF Activity. (Patent No. WO/2014/009295).

@misc{9e8b9770525d48138ba629adf01a569f,

title = "Imidazopyridine Derivatives as Modulators of TNF Activity",

abstract = "A series of imidazo[l,2-a]pyridine derivatives of formula (I), being potent modulators of human TNFa activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorders; and oncological disorders.",

author = "Bentley, \{Jonathan Mark\} and Brookings, \{Daniel Christopher\} and Brown, \{Julien Alistair\} and Cain, \{Thomas Paul\} and Chovatia, \{Praful Tulshi\} and Foley, \{Anne Marie\} and Gallimore, \{Ellen Olivia\} and Gleave, \{Laura Jane\} and Alexander Heifetz and Horsley, \{Helen Tracey\} and Hutchings, \{Martin Clive\} and Jackson, \{Victoria Elizabeth\} and Johnson, \{James Andrew\} and Craig Johnstone and Boris Kroeplien and Comte, \{Fabien Claude\} and Deborah Leigh and Lowe, \{Martin Alexander\} and James Madden and Porter, \{John Robert\} and Quincey, \{Joanna Rachel\} and Reed, \{Laura Claire\} and Reuberson, \{James Thomas\} and Anthony Richardson and Richardson, \{Sarah Emily\} and Selby, \{Matthew Duncan\} and Shaw, \{Michael Alan\} and Zhaoning Zhu",

year = "2014",

month = jan,

day = "16",

language = "English",

type = "Patent",

note = "WO/2014/009295; C07D 471/04 2006.1,C07D 471/04 2006.1,A61K 31/437 2006.1,A61P 29/00 2006.1",

}

Bentley, JM, Brookings, DC, Brown, JA, Cain, TP, Chovatia, PT, Foley, AM, Gallimore, EO, Gleave, LJ, Heifetz, A, Horsley, HT, Hutchings, MC, Jackson, VE, Johnson, JA, Johnstone, C, Kroeplien, B, Comte, FC, Leigh, D, Lowe, MA, Madden, J, Porter, JR, Quincey, JR, Reed, LC, Reuberson, JT, Richardson, A, Richardson, SE, Selby, MD, Shaw, MA & Zhu, Z Jan. 16 2014, Imidazopyridine Derivatives as Modulators of TNF Activity, Patent No. WO/2014/009295.

TY - PAT

T1 - Imidazopyridine Derivatives as Modulators of TNF Activity

AU - Bentley, Jonathan Mark

AU - Brookings, Daniel Christopher

AU - Brown, Julien Alistair

AU - Cain, Thomas Paul

AU - Chovatia, Praful Tulshi

AU - Foley, Anne Marie

AU - Gallimore, Ellen Olivia

AU - Gleave, Laura Jane

AU - Heifetz, Alexander

AU - Horsley, Helen Tracey

AU - Hutchings, Martin Clive

AU - Jackson, Victoria Elizabeth

AU - Johnson, James Andrew

AU - Johnstone, Craig

AU - Kroeplien, Boris

AU - Comte, Fabien Claude

AU - Leigh, Deborah

AU - Lowe, Martin Alexander

AU - Madden, James

AU - Porter, John Robert

AU - Quincey, Joanna Rachel

AU - Reed, Laura Claire

AU - Reuberson, James Thomas

AU - Richardson, Anthony

AU - Richardson, Sarah Emily

AU - Selby, Matthew Duncan

AU - Shaw, Michael Alan

AU - Zhu, Zhaoning

PY - 2014/1/16

Y1 - 2014/1/16

N2 - A series of imidazo[l,2-a]pyridine derivatives of formula (I), being potent modulators of human TNFa activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorders; and oncological disorders.

AB - A series of imidazo[l,2-a]pyridine derivatives of formula (I), being potent modulators of human TNFa activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorders; and oncological disorders.

UR - https://patentscope.wipo.int/search/en/detail.jsf?docId=WO2014009295&_cid=P10-KXITHU-43913-1

M3 - Patent

M1 - WO/2014/009295

Y2 - 2013/07/05

ER -

Imidazopyridine Derivatives as Modulators of TNF Activity

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