Immune diseases caused by mutations in kinases and components of the ubiquitin system

Philip Cohen

doi:10.1038/ni.2892

Immune diseases caused by mutations in kinases and components of the ubiquitin system

Philip Cohen

Research output: Contribution to journal › Review article › peer-review

35 Citations (Scopus)

Abstract

The signaling networks that control the immune system are coordinated by a myriad of interconnecting phosphorylation and ubiquitylation events. This review provides an overview of mutations in human genes encoding these proteins that give rise to immune diseases. Analysis of the biological effects of these mutations has revealed the true physiological roles of particular signaling networks and promises to revolutionize the treatment of these diseases.

Original language	English
Pages (from-to)	521-529
Number of pages	9
Journal	Nature Immunology
Volume	15
Issue number	6
Early online date	9 May 2014
DOIs	https://doi.org/10.1038/ni.2892
Publication status	Published - Jun 2014

Keywords

Immunological disorders
Innate immune cells

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1038/ni.2892

Characterisation of Signal Transduction Pathways that Restrict Activation of the Innate Immune System to Prevent Inflammatory and Autoimmune Diseases (Programme Grant)
Cohen, P. (Investigator)
Medical Research Council
1/04/13 → 31/03/18
Project: Research
Elucidation of Molecular Mechanisms that Activate the MyD88 Signaling Network (Senior Investigator Award)
Cohen, P. (Investigator)
1/04/13 → 31/03/18
Project: Research

Cite this

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AB - The signaling networks that control the immune system are coordinated by a myriad of interconnecting phosphorylation and ubiquitylation events. This review provides an overview of mutations in human genes encoding these proteins that give rise to immune diseases. Analysis of the biological effects of these mutations has revealed the true physiological roles of particular signaling networks and promises to revolutionize the treatment of these diseases.

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KW - Innate immune cells

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Immune diseases caused by mutations in kinases and components of the ubiquitin system

Abstract

Keywords

UN SDGs

Access to Document

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Projects

Characterisation of Signal Transduction Pathways that Restrict Activation of the Innate Immune System to Prevent Inflammatory and Autoimmune Diseases (Programme Grant)

Elucidation of Molecular Mechanisms that Activate the MyD88 Signaling Network (Senior Investigator Award)

Cite this