Immune diseases caused by mutations in kinases and components of the ubiquitin system

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    26 Citations (Scopus)

    Abstract

    The signaling networks that control the immune system are coordinated by a myriad of interconnecting phosphorylation and ubiquitylation events. This review provides an overview of mutations in human genes encoding these proteins that give rise to immune diseases. Analysis of the biological effects of these mutations has revealed the true physiological roles of particular signaling networks and promises to revolutionize the treatment of these diseases.
    Original languageEnglish
    Pages (from-to)521-529
    Number of pages9
    JournalNature Immunology
    Volume15
    Issue number6
    Early online date9 May 2014
    DOIs
    Publication statusPublished - Jun 2014

    Keywords

    • Immunological disorders
    • Innate immune cells

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