Projects per year
The signaling networks that control the immune system are coordinated by a myriad of interconnecting phosphorylation and ubiquitylation events. This review provides an overview of mutations in human genes encoding these proteins that give rise to immune diseases. Analysis of the biological effects of these mutations has revealed the true physiological roles of particular signaling networks and promises to revolutionize the treatment of these diseases.
- Immunological disorders
- Innate immune cells
Elucidation of Molecular Mechanisms that Activate the MyD88 Signaling Network (Senior Investigator Award)
1/04/13 → 31/03/18