Immuno-materials: exploring the translational aspects among immunology, biomaterials and biomedicine

Marco Tatullo; Andrea Pacifici; Roberta Ruggiero; Fabiana Innocenzi; Gianfranco Palumbo; Anastasia Facente; Francesco Paduano

doi:10.37349/ei.2026.1003242

Immuno-materials: exploring the translational aspects among immunology, biomaterials and biomedicine

Marco Tatullo (Lead / Corresponding author)
, Andrea Pacifici
, Roberta Ruggiero
, Fabiana Innocenzi
, Gianfranco Palumbo
, Anastasia Facente
, Francesco Paduano

Dentistry

Research output: Contribution to journal › Review article › peer-review

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Abstract

Immuno-materials, which represent a confluence of immunology and materials science, are dramatically transforming the fields of healthcare. Through the targeted modulation of immune responses, these innovative materials offer promising avenues for advancements in vaccine development, immunotherapy, tissue engineering, and diagnostics. This review examines the fundamental principles of immuno-materials, elucidating key concepts and methodologies pertinent to their development. We investigate strategies for engineering materials that can elicit customized immune responses, capable of both stimulation and suppression, and we discuss their potential roles as adjuvants, carriers, or scaffolds. Furthermore, we address the challenges and opportunities associated with the clinical translation of these materials, emphasizing the critical importance of biocompatibility, safety, and efficacy. This review aims to critically evaluate and contextualize the transformative potential of immuno-materials, mapping their journey from laboratory design to proven clinical applications in enhancing human health.

Original language	English
Article number	1003242
Journal	Exploration of Immunology
Volume	6
DOIs	https://doi.org/10.37349/ei.2026.1003242
Publication status	Published - 29 Mar 2026

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

bio-interface
immune homeostasis
immunology
materials

ASJC Scopus subject areas

Microbiology
Immunology
Immunology and Microbiology (miscellaneous)

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10.37349/ei.2026.1003242Licence: CC BY

Final published version
© The Author(s) 2026. This is an Open Access article licensed under a Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, sharing, adaptation, distribution and reproduction in any medium or format, for any purpose, even commercially, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
Final published version, 3.01 MBLicence: CC BY

Cite this

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title = "Immuno-materials: exploring the translational aspects among immunology, biomaterials and biomedicine",

abstract = "Immuno-materials, which represent a confluence of immunology and materials science, are dramatically transforming the fields of healthcare. Through the targeted modulation of immune responses, these innovative materials offer promising avenues for advancements in vaccine development, immunotherapy, tissue engineering, and diagnostics. This review examines the fundamental principles of immuno-materials, elucidating key concepts and methodologies pertinent to their development. We investigate strategies for engineering materials that can elicit customized immune responses, capable of both stimulation and suppression, and we discuss their potential roles as adjuvants, carriers, or scaffolds. Furthermore, we address the challenges and opportunities associated with the clinical translation of these materials, emphasizing the critical importance of biocompatibility, safety, and efficacy. This review aims to critically evaluate and contextualize the transformative potential of immuno-materials, mapping their journey from laboratory design to proven clinical applications in enhancing human health.",

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T2 - exploring the translational aspects among immunology, biomaterials and biomedicine

AU - Tatullo, Marco

AU - Pacifici, Andrea

AU - Ruggiero, Roberta

AU - Innocenzi, Fabiana

AU - Palumbo, Gianfranco

AU - Facente, Anastasia

AU - Paduano, Francesco

PY - 2026/3/29

Y1 - 2026/3/29

N2 - Immuno-materials, which represent a confluence of immunology and materials science, are dramatically transforming the fields of healthcare. Through the targeted modulation of immune responses, these innovative materials offer promising avenues for advancements in vaccine development, immunotherapy, tissue engineering, and diagnostics. This review examines the fundamental principles of immuno-materials, elucidating key concepts and methodologies pertinent to their development. We investigate strategies for engineering materials that can elicit customized immune responses, capable of both stimulation and suppression, and we discuss their potential roles as adjuvants, carriers, or scaffolds. Furthermore, we address the challenges and opportunities associated with the clinical translation of these materials, emphasizing the critical importance of biocompatibility, safety, and efficacy. This review aims to critically evaluate and contextualize the transformative potential of immuno-materials, mapping their journey from laboratory design to proven clinical applications in enhancing human health.

AB - Immuno-materials, which represent a confluence of immunology and materials science, are dramatically transforming the fields of healthcare. Through the targeted modulation of immune responses, these innovative materials offer promising avenues for advancements in vaccine development, immunotherapy, tissue engineering, and diagnostics. This review examines the fundamental principles of immuno-materials, elucidating key concepts and methodologies pertinent to their development. We investigate strategies for engineering materials that can elicit customized immune responses, capable of both stimulation and suppression, and we discuss their potential roles as adjuvants, carriers, or scaffolds. Furthermore, we address the challenges and opportunities associated with the clinical translation of these materials, emphasizing the critical importance of biocompatibility, safety, and efficacy. This review aims to critically evaluate and contextualize the transformative potential of immuno-materials, mapping their journey from laboratory design to proven clinical applications in enhancing human health.

KW - bio-interface

KW - immune homeostasis

KW - immunology

KW - materials

UR - https://www.scopus.com/pages/publications/105034935323

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DO - 10.37349/ei.2026.1003242

M3 - Review article

AN - SCOPUS:105034935323

VL - 6

JO - Exploration of Immunology

JF - Exploration of Immunology

M1 - 1003242

ER -

Immuno-materials: exploring the translational aspects among immunology, biomaterials and biomedicine

Abstract

UN SDGs

Keywords

ASJC Scopus subject areas

Access to Document

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