Immunocytochemical evidence for transferrin-dependent proliferation during renal tubulogenesis

S. Fleming, D. B. Jones

    Research output: Contribution to journalArticle

    11 Citations (Scopus)

    Abstract

    The role of the transferrin receptor and of cell proliferation during human renal embryogenesis has been studied by using immunocytochemical techniques. Tissue sections of human fetal kidneys have been stained using monoclonal antibodies to the cell surface transferrin receptor (HB21) and the nuclear proliferation antigen (Ki67). Both antigens appear during nephron induction, are strongly expressed during the early stages of renal tubulogenesis, but are lost with progressive maturation. Simultaneous changes in the intermediate filament phenotype at this developmental stage have also been demonstrated by the use of monoclonal antibodies to vimentin and low molecular weight cytokeratin. This study provides immunocytochemical evidence that in the human kidney, as in in vitro development of the mouse kidney, one of the early events in tubule induction involves transferrin-dependent proliferation.
    Original languageEnglish
    Pages (from-to)191-201
    Number of pages11
    JournalJournal of Anatomy
    Volume153
    Issue number1
    Publication statusPublished - 1987

    Fingerprint

    transferrin
    Transferrin
    antigen
    antibody
    kidneys
    Kidney
    developmental stage
    Transferrin Receptors
    phenotype
    maturation
    monoclonal antibodies
    Monoclonal Antibodies
    Ki-67 Antigen
    antigens
    intermediate filaments
    nephrons
    Nuclear Antigens
    receptors
    Intermediate Filaments
    vimentin

    Cite this

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    title = "Immunocytochemical evidence for transferrin-dependent proliferation during renal tubulogenesis",
    abstract = "The role of the transferrin receptor and of cell proliferation during human renal embryogenesis has been studied by using immunocytochemical techniques. Tissue sections of human fetal kidneys have been stained using monoclonal antibodies to the cell surface transferrin receptor (HB21) and the nuclear proliferation antigen (Ki67). Both antigens appear during nephron induction, are strongly expressed during the early stages of renal tubulogenesis, but are lost with progressive maturation. Simultaneous changes in the intermediate filament phenotype at this developmental stage have also been demonstrated by the use of monoclonal antibodies to vimentin and low molecular weight cytokeratin. This study provides immunocytochemical evidence that in the human kidney, as in in vitro development of the mouse kidney, one of the early events in tubule induction involves transferrin-dependent proliferation.",
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    language = "English",
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    Immunocytochemical evidence for transferrin-dependent proliferation during renal tubulogenesis. / Fleming, S.; Jones, D. B.

    In: Journal of Anatomy, Vol. 153, No. 1, 1987, p. 191-201.

    Research output: Contribution to journalArticle

    TY - JOUR

    T1 - Immunocytochemical evidence for transferrin-dependent proliferation during renal tubulogenesis

    AU - Fleming, S.

    AU - Jones, D. B.

    PY - 1987

    Y1 - 1987

    N2 - The role of the transferrin receptor and of cell proliferation during human renal embryogenesis has been studied by using immunocytochemical techniques. Tissue sections of human fetal kidneys have been stained using monoclonal antibodies to the cell surface transferrin receptor (HB21) and the nuclear proliferation antigen (Ki67). Both antigens appear during nephron induction, are strongly expressed during the early stages of renal tubulogenesis, but are lost with progressive maturation. Simultaneous changes in the intermediate filament phenotype at this developmental stage have also been demonstrated by the use of monoclonal antibodies to vimentin and low molecular weight cytokeratin. This study provides immunocytochemical evidence that in the human kidney, as in in vitro development of the mouse kidney, one of the early events in tubule induction involves transferrin-dependent proliferation.

    AB - The role of the transferrin receptor and of cell proliferation during human renal embryogenesis has been studied by using immunocytochemical techniques. Tissue sections of human fetal kidneys have been stained using monoclonal antibodies to the cell surface transferrin receptor (HB21) and the nuclear proliferation antigen (Ki67). Both antigens appear during nephron induction, are strongly expressed during the early stages of renal tubulogenesis, but are lost with progressive maturation. Simultaneous changes in the intermediate filament phenotype at this developmental stage have also been demonstrated by the use of monoclonal antibodies to vimentin and low molecular weight cytokeratin. This study provides immunocytochemical evidence that in the human kidney, as in in vitro development of the mouse kidney, one of the early events in tubule induction involves transferrin-dependent proliferation.

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    EP - 201

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