Immunoglobulin A: Molecular mechanisms of function and role in immune defence

    Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

    3 Citations (Scopus)

    Abstract

    Our immune system produces more immunoglobulin A (IgA) than all of the other antibody classes combined. Much of this synthesis is directed towards protection of the mucosal surfaces which form a vast and vulnerable interface with the environment. As the predominant immunoglobulin class at these surfaces, IgA is an important first line of defence. In addition, IgA is also a major serum immunoglobulin. Both monomeric IgA in serum and polymeric secretory forms of IgA mediate a wide range of protective functions through interaction with numerous receptors and other mediators. It is telling that in order to gain better opportunities for invasion, certain pathogens have evolved mechanisms to thwart IgA function. An improved understanding of this multifaceted immunoglobulin is likely to inform strategies for improved treatments for infections and other diseases.

    Original languageEnglish
    Title of host publicationMolecular and Cellular Mechanisms of Antibody Activity
    EditorsFalk Nimmerjahn
    PublisherSpringer New York
    Chapter2
    Pages31-60
    Number of pages30
    ISBN (Electronic)9781461471073
    ISBN (Print)9781461471066
    DOIs
    Publication statusPublished - 29 Apr 2013

    Keywords

    • Dimeric IgA
    • Glycosylation
    • IgA
    • IgA receptors
    • IgA1
    • IgA2
    • Immune defence
    • Immunoglobulin A

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  • Cite this

    Woof, J. M. (2013). Immunoglobulin A: Molecular mechanisms of function and role in immune defence. In F. Nimmerjahn (Ed.), Molecular and Cellular Mechanisms of Antibody Activity (pp. 31-60). Springer New York. https://doi.org/10.1007/978-1-4614-7107-3_2