Impact of methicillin-resistant staphylococcus aureus (MRSA) infection on patient outcome after pancreatoduodenectomy (PD)

a cause for concern?

Pandanaboyana Sanjay, Ali Fawzi, Christoph Kulli, Francesco M. Polignano, Iain S. Tait

    Research output: Contribution to journalArticle

    7 Citations (Scopus)

    Abstract

    Objectives: This study evaluated the impact of methicillin-resistant Staphylococcus aureus (MRSA) hospital-acquired infection on postoperative complications and patient outcome after pancreatoduodenectomy (PD). Methods: Seventy-nine patients who underwent PD were monitored for hospital-acquired MRSA. The patients were grouped as (1) no MRSA infection, (2) skin colonization with MRSA, and (3) systemic MRSA infection. Results: Forty (51%) of the 79 patients were MRSA positive during hospital admission. Fourteen of the 40 patients swabbed for MRSA were found positive (skin colonization), and 26 patients (33%) developed systemic MRSA infection after PD. The sites of MRSA infection included (1) abdominal drain fluid (16/26; 42%), (2) sputum (4/26; 15%), (3) blood cultures (2/26; 8%), and (4) combination of sites (9/26; 35%). The patients with systemic MRSA infection had a longer postoperative stay (31 vs 22 days; P = 0.005) and increased incidence of chest infections compared with MRSA-negative patients (14 vs 4; P = 0.02). Four of the 16 patients with MRSA-positive drain fluid had a postpancreatectomy hemorrhage compared with 3 of the 63 patients with no MRSA infection in drain fluid (P = 0.02). Conclusion: Of the 79 patients admitted for PD, 51% became colonized with MRSA infection. Systemic hospital-acquired MRSA infection in 33% was associated with prolonged postoperative stay, increased wound and chest infections, and increased risk of postoperative hemorrhage.
    Original languageEnglish
    Pages (from-to)1211-1214
    Number of pages4
    JournalPancreas
    Volume39
    Issue number8
    DOIs
    Publication statusPublished - 1 Nov 2010

    Fingerprint

    Pancreaticoduodenectomy
    Methicillin-Resistant Staphylococcus aureus
    Infection
    Thorax
    Postoperative Hemorrhage
    Skin
    Wound Infection
    Cross Infection
    Sputum

    Keywords

    • Pancreatoduodenectomy
    • Infection
    • MRSA

    Cite this

    Sanjay, Pandanaboyana ; Fawzi, Ali ; Kulli, Christoph ; Polignano, Francesco M. ; Tait, Iain S. / Impact of methicillin-resistant staphylococcus aureus (MRSA) infection on patient outcome after pancreatoduodenectomy (PD) : a cause for concern?. In: Pancreas. 2010 ; Vol. 39, No. 8. pp. 1211-1214.
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    title = "Impact of methicillin-resistant staphylococcus aureus (MRSA) infection on patient outcome after pancreatoduodenectomy (PD): a cause for concern?",
    abstract = "Objectives: This study evaluated the impact of methicillin-resistant Staphylococcus aureus (MRSA) hospital-acquired infection on postoperative complications and patient outcome after pancreatoduodenectomy (PD). Methods: Seventy-nine patients who underwent PD were monitored for hospital-acquired MRSA. The patients were grouped as (1) no MRSA infection, (2) skin colonization with MRSA, and (3) systemic MRSA infection. Results: Forty (51{\%}) of the 79 patients were MRSA positive during hospital admission. Fourteen of the 40 patients swabbed for MRSA were found positive (skin colonization), and 26 patients (33{\%}) developed systemic MRSA infection after PD. The sites of MRSA infection included (1) abdominal drain fluid (16/26; 42{\%}), (2) sputum (4/26; 15{\%}), (3) blood cultures (2/26; 8{\%}), and (4) combination of sites (9/26; 35{\%}). The patients with systemic MRSA infection had a longer postoperative stay (31 vs 22 days; P = 0.005) and increased incidence of chest infections compared with MRSA-negative patients (14 vs 4; P = 0.02). Four of the 16 patients with MRSA-positive drain fluid had a postpancreatectomy hemorrhage compared with 3 of the 63 patients with no MRSA infection in drain fluid (P = 0.02). Conclusion: Of the 79 patients admitted for PD, 51{\%} became colonized with MRSA infection. Systemic hospital-acquired MRSA infection in 33{\%} was associated with prolonged postoperative stay, increased wound and chest infections, and increased risk of postoperative hemorrhage.",
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    Impact of methicillin-resistant staphylococcus aureus (MRSA) infection on patient outcome after pancreatoduodenectomy (PD) : a cause for concern? / Sanjay, Pandanaboyana; Fawzi, Ali; Kulli, Christoph; Polignano, Francesco M.; Tait, Iain S.

    In: Pancreas, Vol. 39, No. 8, 01.11.2010, p. 1211-1214.

    Research output: Contribution to journalArticle

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    T1 - Impact of methicillin-resistant staphylococcus aureus (MRSA) infection on patient outcome after pancreatoduodenectomy (PD)

    T2 - a cause for concern?

    AU - Sanjay, Pandanaboyana

    AU - Fawzi, Ali

    AU - Kulli, Christoph

    AU - Polignano, Francesco M.

    AU - Tait, Iain S.

    N1 - MEDLINE® is the source for the MeSH terms of this document.

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    N2 - Objectives: This study evaluated the impact of methicillin-resistant Staphylococcus aureus (MRSA) hospital-acquired infection on postoperative complications and patient outcome after pancreatoduodenectomy (PD). Methods: Seventy-nine patients who underwent PD were monitored for hospital-acquired MRSA. The patients were grouped as (1) no MRSA infection, (2) skin colonization with MRSA, and (3) systemic MRSA infection. Results: Forty (51%) of the 79 patients were MRSA positive during hospital admission. Fourteen of the 40 patients swabbed for MRSA were found positive (skin colonization), and 26 patients (33%) developed systemic MRSA infection after PD. The sites of MRSA infection included (1) abdominal drain fluid (16/26; 42%), (2) sputum (4/26; 15%), (3) blood cultures (2/26; 8%), and (4) combination of sites (9/26; 35%). The patients with systemic MRSA infection had a longer postoperative stay (31 vs 22 days; P = 0.005) and increased incidence of chest infections compared with MRSA-negative patients (14 vs 4; P = 0.02). Four of the 16 patients with MRSA-positive drain fluid had a postpancreatectomy hemorrhage compared with 3 of the 63 patients with no MRSA infection in drain fluid (P = 0.02). Conclusion: Of the 79 patients admitted for PD, 51% became colonized with MRSA infection. Systemic hospital-acquired MRSA infection in 33% was associated with prolonged postoperative stay, increased wound and chest infections, and increased risk of postoperative hemorrhage.

    AB - Objectives: This study evaluated the impact of methicillin-resistant Staphylococcus aureus (MRSA) hospital-acquired infection on postoperative complications and patient outcome after pancreatoduodenectomy (PD). Methods: Seventy-nine patients who underwent PD were monitored for hospital-acquired MRSA. The patients were grouped as (1) no MRSA infection, (2) skin colonization with MRSA, and (3) systemic MRSA infection. Results: Forty (51%) of the 79 patients were MRSA positive during hospital admission. Fourteen of the 40 patients swabbed for MRSA were found positive (skin colonization), and 26 patients (33%) developed systemic MRSA infection after PD. The sites of MRSA infection included (1) abdominal drain fluid (16/26; 42%), (2) sputum (4/26; 15%), (3) blood cultures (2/26; 8%), and (4) combination of sites (9/26; 35%). The patients with systemic MRSA infection had a longer postoperative stay (31 vs 22 days; P = 0.005) and increased incidence of chest infections compared with MRSA-negative patients (14 vs 4; P = 0.02). Four of the 16 patients with MRSA-positive drain fluid had a postpancreatectomy hemorrhage compared with 3 of the 63 patients with no MRSA infection in drain fluid (P = 0.02). Conclusion: Of the 79 patients admitted for PD, 51% became colonized with MRSA infection. Systemic hospital-acquired MRSA infection in 33% was associated with prolonged postoperative stay, increased wound and chest infections, and increased risk of postoperative hemorrhage.

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