Impact of SARS-CoV-2 pandemic on pancreatic cancer services and treatment pathways: United Kingdom experience

Siobhan C. McKay; Samir Pathak; Richard J.W. Wilkin; Sivesh K. Kamarajah; Stephen J. Wigmore; Jonathan Rees; Declan F.J. Dunne; Giuseppe Garcea; Jawad Ahmad; Nicola de Liguori Carino; Asma Sultana; Mike Silva; Pavlos Lykoudis; David Nasralla; James Milburn; Nehal Shah; Hemant M. Kocher; Ricky Bhogal; Ryan D. Baron; Alex Navarro; James Halle-Smith; Bilal Al-Sarireh; Gourab Sen; Nigel B. Jamieson; Christopher Briggs; David Stell; Somaiah Aroori; Matthew Bowles; Aditya Kanwar; Simon Harper; Krishna Menon; Andreas Prachalias; Parthi Srinivasan; Adam E. Frampton; Claire Jones; Ali Arshad; Iain Tait; Duncan Spalding; Alastair L. Young; Damien Durkin; Manijeh Ghods-Ghorbani; Robert P. Sutcliffe; Keith J. Roberts

doi:10.1016/j.hpb.2021.03.003

Impact of SARS-CoV-2 pandemic on pancreatic cancer services and treatment pathways: United Kingdom experience

Siobhan C. McKay (Lead / Corresponding author), Samir Pathak, Richard J.W. Wilkin, Sivesh K. Kamarajah, Stephen J. Wigmore, Jonathan Rees, Declan F.J. Dunne, Giuseppe Garcea, Jawad Ahmad, Nicola de Liguori Carino, Asma Sultana, Mike Silva, Pavlos Lykoudis, David Nasralla, James Milburn, Nehal Shah, Hemant M. Kocher, Ricky Bhogal, Ryan D. Baron, Alex NavarroJames Halle-Smith, Bilal Al-Sarireh, Gourab Sen, Nigel B. Jamieson, Christopher Briggs, David Stell, Somaiah Aroori, Matthew Bowles, Aditya Kanwar, Simon Harper, Krishna Menon, Andreas Prachalias, Parthi Srinivasan, Adam E. Frampton, Claire Jones, Ali Arshad, Iain Tait, Duncan Spalding, Alastair L. Young, Damien Durkin, Manijeh Ghods-Ghorbani, Robert P. Sutcliffe, Keith J. Roberts

Undergraduate Medicine

Research output: Contribution to journal › Article › peer-review

14 Citations (Scopus)

Abstract

Introduction: The SARS-CoV-2 pandemic presented healthcare providers with an extreme challenge to provide cancer services. The impact upon the diagnostic and treatment capacity to treat pancreatic cancer is unclear. This study aimed to identify national variation in treatment pathways during the pandemic.

Methods: A survey was distributed to all United Kingdom pancreatic specialist centres, to assess diagnostic, therapeutic and interventional services availability, and alterations in treatment pathways. A repeating methodology enabled assessment over time as the pandemic evolved.

Results: Responses were received from all 29 centres. Over the first six weeks of the pandemic, less than a quarter of centres had normal availability of diagnostic pathways and a fifth of centres had no capacity whatsoever to undertake surgery. As the pandemic progressed services have gradually improved though most centres remain constrained to some degree. One third of centres changed their standard resectable pathway from surgery-first to neoadjuvant chemotherapy. Elderly patients, and those with COPD were less likely to be offered treatment during the pandemic.

Conclusion: The COVID-19 pandemic has affected the capacity of the NHS to provide diagnostic and staging investigations for pancreatic cancer. The impact of revised treatment pathways has yet to be realised.

Original language	English
Pages (from-to)	1656-1665
Number of pages	10
Journal	HPB
Volume	23
Issue number	11
Early online date	19 Mar 2021
DOIs	https://doi.org/10.1016/j.hpb.2021.03.003
Publication status	Published - Nov 2021

ASJC Scopus subject areas

Hepatology
Gastroenterology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.hpb.2021.03.003Licence: Elsevier User Licence

Cite this

McKay, S. C., Pathak, S., Wilkin, R. J. W., Kamarajah, S. K., Wigmore, S. J., Rees, J., Dunne, D. F. J., Garcea, G., Ahmad, J., de Liguori Carino, N., Sultana, A., Silva, M., Lykoudis, P., Nasralla, D., Milburn, J., Shah, N., Kocher, H. M., Bhogal, R., Baron, R. D., ... Roberts, K. J. (2021). Impact of SARS-CoV-2 pandemic on pancreatic cancer services and treatment pathways: United Kingdom experience. HPB, 23(11), 1656-1665. https://doi.org/10.1016/j.hpb.2021.03.003

@article{cf8992440692426fb8d2ace079223a6f,

title = "Impact of SARS-CoV-2 pandemic on pancreatic cancer services and treatment pathways: United Kingdom experience",

abstract = "Introduction: The SARS-CoV-2 pandemic presented healthcare providers with an extreme challenge to provide cancer services. The impact upon the diagnostic and treatment capacity to treat pancreatic cancer is unclear. This study aimed to identify national variation in treatment pathways during the pandemic.Methods: A survey was distributed to all United Kingdom pancreatic specialist centres, to assess diagnostic, therapeutic and interventional services availability, and alterations in treatment pathways. A repeating methodology enabled assessment over time as the pandemic evolved.Results: Responses were received from all 29 centres. Over the first six weeks of the pandemic, less than a quarter of centres had normal availability of diagnostic pathways and a fifth of centres had no capacity whatsoever to undertake surgery. As the pandemic progressed services have gradually improved though most centres remain constrained to some degree. One third of centres changed their standard resectable pathway from surgery-first to neoadjuvant chemotherapy. Elderly patients, and those with COPD were less likely to be offered treatment during the pandemic.Conclusion: The COVID-19 pandemic has affected the capacity of the NHS to provide diagnostic and staging investigations for pancreatic cancer. The impact of revised treatment pathways has yet to be realised.",

author = "McKay, {Siobhan C.} and Samir Pathak and Wilkin, {Richard J.W.} and Kamarajah, {Sivesh K.} and Wigmore, {Stephen J.} and Jonathan Rees and Dunne, {Declan F.J.} and Giuseppe Garcea and Jawad Ahmad and {de Liguori Carino}, Nicola and Asma Sultana and Mike Silva and Pavlos Lykoudis and David Nasralla and James Milburn and Nehal Shah and Kocher, {Hemant M.} and Ricky Bhogal and Baron, {Ryan D.} and Alex Navarro and James Halle-Smith and Bilal Al-Sarireh and Gourab Sen and Jamieson, {Nigel B.} and Christopher Briggs and David Stell and Somaiah Aroori and Matthew Bowles and Aditya Kanwar and Simon Harper and Krishna Menon and Andreas Prachalias and Parthi Srinivasan and Frampton, {Adam E.} and Claire Jones and Ali Arshad and Iain Tait and Duncan Spalding and Young, {Alastair L.} and Damien Durkin and Manijeh Ghods-Ghorbani and Sutcliffe, {Robert P.} and Roberts, {Keith J.}",

note = "Funding Information: We would like to thank the Association of Upper Gastrointestinal Surgery (AUGIS), the Royal College of Surgeons of England (RCS Eng), the Pancreatic Society of Great Britain and Ireland (PSGBI), and Pancreatic Cancer UK (PCUK) for their help. We also thank the Birmingham Surgical Trials Consortium (BiSTC) for their assistance with administration of the surveys. Publisher Copyright: {\textcopyright} 2021 Published by Elsevier Ltd on behalf of International Hepato-Pancreato-Biliary Association Inc.",

year = "2021",

month = nov,

doi = "10.1016/j.hpb.2021.03.003",

language = "English",

volume = "23",

pages = "1656--1665",

journal = "HPB",

issn = "1365-182X",

publisher = "Elsevier",

number = "11",

}

McKay, SC, Pathak, S, Wilkin, RJW, Kamarajah, SK, Wigmore, SJ, Rees, J, Dunne, DFJ, Garcea, G, Ahmad, J, de Liguori Carino, N, Sultana, A, Silva, M, Lykoudis, P, Nasralla, D, Milburn, J, Shah, N, Kocher, HM, Bhogal, R, Baron, RD, Navarro, A, Halle-Smith, J, Al-Sarireh, B, Sen, G, Jamieson, NB, Briggs, C, Stell, D, Aroori, S, Bowles, M, Kanwar, A, Harper, S, Menon, K, Prachalias, A, Srinivasan, P, Frampton, AE, Jones, C, Arshad, A, Tait, I, Spalding, D, Young, AL, Durkin, D, Ghods-Ghorbani, M, Sutcliffe, RP & Roberts, KJ 2021, 'Impact of SARS-CoV-2 pandemic on pancreatic cancer services and treatment pathways: United Kingdom experience', HPB, vol. 23, no. 11, pp. 1656-1665. https://doi.org/10.1016/j.hpb.2021.03.003

TY - JOUR

T1 - Impact of SARS-CoV-2 pandemic on pancreatic cancer services and treatment pathways

T2 - United Kingdom experience

AU - McKay, Siobhan C.

AU - Pathak, Samir

AU - Wilkin, Richard J.W.

AU - Kamarajah, Sivesh K.

AU - Wigmore, Stephen J.

AU - Rees, Jonathan

AU - Dunne, Declan F.J.

AU - Garcea, Giuseppe

AU - Ahmad, Jawad

AU - de Liguori Carino, Nicola

AU - Sultana, Asma

AU - Silva, Mike

AU - Lykoudis, Pavlos

AU - Nasralla, David

AU - Milburn, James

AU - Shah, Nehal

AU - Kocher, Hemant M.

AU - Bhogal, Ricky

AU - Baron, Ryan D.

AU - Navarro, Alex

AU - Halle-Smith, James

AU - Al-Sarireh, Bilal

AU - Sen, Gourab

AU - Jamieson, Nigel B.

AU - Briggs, Christopher

AU - Stell, David

AU - Aroori, Somaiah

AU - Bowles, Matthew

AU - Kanwar, Aditya

AU - Harper, Simon

AU - Menon, Krishna

AU - Prachalias, Andreas

AU - Srinivasan, Parthi

AU - Frampton, Adam E.

AU - Jones, Claire

AU - Arshad, Ali

AU - Tait, Iain

AU - Spalding, Duncan

AU - Young, Alastair L.

AU - Durkin, Damien

AU - Ghods-Ghorbani, Manijeh

AU - Sutcliffe, Robert P.

AU - Roberts, Keith J.

N1 - Funding Information: We would like to thank the Association of Upper Gastrointestinal Surgery (AUGIS), the Royal College of Surgeons of England (RCS Eng), the Pancreatic Society of Great Britain and Ireland (PSGBI), and Pancreatic Cancer UK (PCUK) for their help. We also thank the Birmingham Surgical Trials Consortium (BiSTC) for their assistance with administration of the surveys. Publisher Copyright: © 2021 Published by Elsevier Ltd on behalf of International Hepato-Pancreato-Biliary Association Inc.

PY - 2021/11

Y1 - 2021/11

N2 - Introduction: The SARS-CoV-2 pandemic presented healthcare providers with an extreme challenge to provide cancer services. The impact upon the diagnostic and treatment capacity to treat pancreatic cancer is unclear. This study aimed to identify national variation in treatment pathways during the pandemic.Methods: A survey was distributed to all United Kingdom pancreatic specialist centres, to assess diagnostic, therapeutic and interventional services availability, and alterations in treatment pathways. A repeating methodology enabled assessment over time as the pandemic evolved.Results: Responses were received from all 29 centres. Over the first six weeks of the pandemic, less than a quarter of centres had normal availability of diagnostic pathways and a fifth of centres had no capacity whatsoever to undertake surgery. As the pandemic progressed services have gradually improved though most centres remain constrained to some degree. One third of centres changed their standard resectable pathway from surgery-first to neoadjuvant chemotherapy. Elderly patients, and those with COPD were less likely to be offered treatment during the pandemic.Conclusion: The COVID-19 pandemic has affected the capacity of the NHS to provide diagnostic and staging investigations for pancreatic cancer. The impact of revised treatment pathways has yet to be realised.

AB - Introduction: The SARS-CoV-2 pandemic presented healthcare providers with an extreme challenge to provide cancer services. The impact upon the diagnostic and treatment capacity to treat pancreatic cancer is unclear. This study aimed to identify national variation in treatment pathways during the pandemic.Methods: A survey was distributed to all United Kingdom pancreatic specialist centres, to assess diagnostic, therapeutic and interventional services availability, and alterations in treatment pathways. A repeating methodology enabled assessment over time as the pandemic evolved.Results: Responses were received from all 29 centres. Over the first six weeks of the pandemic, less than a quarter of centres had normal availability of diagnostic pathways and a fifth of centres had no capacity whatsoever to undertake surgery. As the pandemic progressed services have gradually improved though most centres remain constrained to some degree. One third of centres changed their standard resectable pathway from surgery-first to neoadjuvant chemotherapy. Elderly patients, and those with COPD were less likely to be offered treatment during the pandemic.Conclusion: The COVID-19 pandemic has affected the capacity of the NHS to provide diagnostic and staging investigations for pancreatic cancer. The impact of revised treatment pathways has yet to be realised.

UR - http://www.scopus.com/inward/record.url?scp=85115142870&partnerID=8YFLogxK

U2 - 10.1016/j.hpb.2021.03.003

DO - 10.1016/j.hpb.2021.03.003

M3 - Article

C2 - 34544628

AN - SCOPUS:85115142870

SN - 1365-182X

VL - 23

SP - 1656

EP - 1665

JO - HPB

JF - HPB

IS - 11

ER -

Impact of SARS-CoV-2 pandemic on pancreatic cancer services and treatment pathways: United Kingdom experience

Abstract

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this