Impaired electrical signaling disrupts gamma frequency oscillations in connexin 36-deficient mice

Sheriar G. Hormuzdi, Isabel Pais, Fiona E. N. LeBeau, Stephen K. Towers, Andrei Rozov, Eberhard H. Buhl, Miles A. Whittington, Hannah Monyer

    Research output: Contribution to journalArticlepeer-review

    401 Citations (Scopus)

    Abstract

    Neural processing occurs in parallel in distant cortical areas even for simple perceptual tasks. Associated cognitive binding is believed to occur through the interareal synchronization of rhythmic activity in the ? (30–80 Hz) range. Such oscillations arise as an emergent property of the neuronal network and require conventional chemical neurotransmission. To test the potential role of gap junction-mediated electrical signaling in this network property, we generated mice lacking connexin 36, the major neuronal connexin. Here we show that the loss of this protein disrupts ? frequency network oscillations in vitro but leaves high frequency (150 Hz) rhythms, which may involve gap junctions between principal cells (Schmitz et al., 2001), unaffected. Thus, specific connexins differentially deployed throughout cortical networks are likely to regulate different functional aspects of neuronal information processing in the mature brain.
    Original languageEnglish
    Pages (from-to)487-495
    Number of pages9
    JournalNeuron
    Volume31
    Issue number3
    DOIs
    Publication statusPublished - Aug 2001

    Keywords

    • Brain physiology
    • Connexins physiology
    • Hippocampus physiology
    • Nerve net physiology
    • Neurons physiology

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