Impaired microvascular function in normal children: effects of adiposity and poor glucose handling

Faisel Khan, Fiona C. Green, J. Stewart Forsyth, Stephen A. Greene, Andrew D. Morris, Jill J. F. Belch

    Research output: Contribution to journalArticle

    61 Citations (Scopus)

    Abstract

    Clustering of cardiovascular risk factors is thought to occur early in life. The endothelium is an important regulator of microvascular function. We investigated the relationship between microvascular function and cardiovascular risk factors in 145 normal, healthy children aged 11–14 years. Skin microvascular responses, measured using laser Doppler imaging, to iontophoresis of acetylcholine (ACh) and sodium nitroprusside (SNP), were negatively correlated with percentage body fat (r = -0.20, P < 0.05 and r = -0.18, P < 0.05, respectively). Subjects were stratified into quintiles based on 2-h, post-feeding glucose levels. Subjects in the upper glucose quintile (range 7.4–11.4 mmol l-1) showed significantly lower vasodilatation to both ACh (P < 0.005) and SNP (P < 0.02) than those in the lower quintile (range 3.9–4.9 mmol l-1). Waist-to-hip ratio and the fasting insulin resistance index were significantly greater in subjects in the upper quintile than those in the lower quintile (P < 0.001 and P < 0.05, respectively). Additionally, in subjects in the upper glucose quintile, fasting triglyceride correlated with fasting insulin (r = 0.59, P < 0.001) and with the fasting insulin resistance index (r = 0.49, P < 0.009), and plasma levels of cholesterol and 2-h glucose were also correlated (r = 0.40, P < 0.05). In a cross-section of normal children, microvascular function was negatively associated with adiposity. Additionally, in a subgroup of subjects, there was a clustering of high post-feeding glucose, impaired microvascular function, increased insulin resistance and higher central fat distribution. These findings suggest that risk factors for adult cardiovascular disease begin to cluster in normal children, which might have important consequences for development of atherosclerosis later in life.
    Original languageEnglish
    Pages (from-to)705-711
    Number of pages7
    JournalJournal of Physiology
    Volume551
    Issue number2
    DOIs
    Publication statusPublished - Sep 2003

    Fingerprint

    Adiposity
    Fasting
    Glucose
    Insulin Resistance
    Nitroprusside
    Acetylcholine
    Cluster Analysis
    Iontophoresis
    Waist-Hip Ratio
    Vasodilation
    Endothelium
    Adipose Tissue
    Atherosclerosis
    Triglycerides
    Lasers
    Cardiovascular Diseases
    Fats
    Cholesterol
    Handling (Psychology)
    Insulin

    Cite this

    Khan, Faisel ; Green, Fiona C. ; Forsyth, J. Stewart ; Greene, Stephen A. ; Morris, Andrew D. ; Belch, Jill J. F. / Impaired microvascular function in normal children : effects of adiposity and poor glucose handling. In: Journal of Physiology. 2003 ; Vol. 551, No. 2. pp. 705-711.
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    abstract = "Clustering of cardiovascular risk factors is thought to occur early in life. The endothelium is an important regulator of microvascular function. We investigated the relationship between microvascular function and cardiovascular risk factors in 145 normal, healthy children aged 11–14 years. Skin microvascular responses, measured using laser Doppler imaging, to iontophoresis of acetylcholine (ACh) and sodium nitroprusside (SNP), were negatively correlated with percentage body fat (r = -0.20, P < 0.05 and r = -0.18, P < 0.05, respectively). Subjects were stratified into quintiles based on 2-h, post-feeding glucose levels. Subjects in the upper glucose quintile (range 7.4–11.4 mmol l-1) showed significantly lower vasodilatation to both ACh (P < 0.005) and SNP (P < 0.02) than those in the lower quintile (range 3.9–4.9 mmol l-1). Waist-to-hip ratio and the fasting insulin resistance index were significantly greater in subjects in the upper quintile than those in the lower quintile (P < 0.001 and P < 0.05, respectively). Additionally, in subjects in the upper glucose quintile, fasting triglyceride correlated with fasting insulin (r = 0.59, P < 0.001) and with the fasting insulin resistance index (r = 0.49, P < 0.009), and plasma levels of cholesterol and 2-h glucose were also correlated (r = 0.40, P < 0.05). In a cross-section of normal children, microvascular function was negatively associated with adiposity. Additionally, in a subgroup of subjects, there was a clustering of high post-feeding glucose, impaired microvascular function, increased insulin resistance and higher central fat distribution. These findings suggest that risk factors for adult cardiovascular disease begin to cluster in normal children, which might have important consequences for development of atherosclerosis later in life.",
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    Impaired microvascular function in normal children : effects of adiposity and poor glucose handling. / Khan, Faisel; Green, Fiona C.; Forsyth, J. Stewart; Greene, Stephen A.; Morris, Andrew D.; Belch, Jill J. F.

    In: Journal of Physiology, Vol. 551, No. 2, 09.2003, p. 705-711.

    Research output: Contribution to journalArticle

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    T2 - effects of adiposity and poor glucose handling

    AU - Khan, Faisel

    AU - Green, Fiona C.

    AU - Forsyth, J. Stewart

    AU - Greene, Stephen A.

    AU - Morris, Andrew D.

    AU - Belch, Jill J. F.

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    AB - Clustering of cardiovascular risk factors is thought to occur early in life. The endothelium is an important regulator of microvascular function. We investigated the relationship between microvascular function and cardiovascular risk factors in 145 normal, healthy children aged 11–14 years. Skin microvascular responses, measured using laser Doppler imaging, to iontophoresis of acetylcholine (ACh) and sodium nitroprusside (SNP), were negatively correlated with percentage body fat (r = -0.20, P < 0.05 and r = -0.18, P < 0.05, respectively). Subjects were stratified into quintiles based on 2-h, post-feeding glucose levels. Subjects in the upper glucose quintile (range 7.4–11.4 mmol l-1) showed significantly lower vasodilatation to both ACh (P < 0.005) and SNP (P < 0.02) than those in the lower quintile (range 3.9–4.9 mmol l-1). Waist-to-hip ratio and the fasting insulin resistance index were significantly greater in subjects in the upper quintile than those in the lower quintile (P < 0.001 and P < 0.05, respectively). Additionally, in subjects in the upper glucose quintile, fasting triglyceride correlated with fasting insulin (r = 0.59, P < 0.001) and with the fasting insulin resistance index (r = 0.49, P < 0.009), and plasma levels of cholesterol and 2-h glucose were also correlated (r = 0.40, P < 0.05). In a cross-section of normal children, microvascular function was negatively associated with adiposity. Additionally, in a subgroup of subjects, there was a clustering of high post-feeding glucose, impaired microvascular function, increased insulin resistance and higher central fat distribution. These findings suggest that risk factors for adult cardiovascular disease begin to cluster in normal children, which might have important consequences for development of atherosclerosis later in life.

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    DO - 10.1113/jphysiol.2003.045351

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