Impulse control disorders in Parkinson's disease: recent advances

Valerie Voon (Lead / Corresponding author), Arpan R Mehta, Mark Hallett

Research output: Contribution to journalReview articlepeer-review

150 Citations (Scopus)


Purpose of review The aim is to review the recent advances in the epidemiology and pathophysiology of impulse control disorders (ICDs) in Parkinson's disease.
Recent findings Large cross-sectional and case–control multicentre studies show that ICDs in Parkinson's disease are common, with a frequency of 13.6%. These behaviours are associated with impaired functioning and with depressive, anxiety and obsessive symptoms, novelty seeking and impulsivity. Behavioural subtypes demonstrate differences in novelty seeking and impulsivity, suggesting pathophysiological differences. Observational and neurophysiological studies point towards a potential mechanistic overlap between behavioural (ICDs) and motor (dyskinesias) dopaminergic sequelae. Converging data suggest dopamine agonists in ICDs appear to enhance learning from rewarding outcomes and impulsive choice. ICD patients also have enhanced risk preference and impaired working memory. Neuroimaging data point towards enhanced bottom-up ventral striatal dopamine release to incentive cues, gambling tasks and reward prediction, and possible inhibition of top-down orbitofrontal influences. Dopamine agonist-related ventral striatal hypoactivity to risk is consistent with impaired risk evaluation.
Summary Recent large-scale studies and converging findings are beginning to provide an understanding of mechanisms underlying ICDs in Parkinson's disease, which can guide prevention of these behaviours and optimize therapeutic approaches.
Original languageEnglish
Pages (from-to)324-330
Number of pages7
JournalCurrent opinion in neurology
Issue number4
Publication statusPublished - Aug 2011


  • Impulse control disorders
  • Parkinson’s disease
  • dopamine agonists
  • pathological gambling
  • impulsivity


Dive into the research topics of 'Impulse control disorders in Parkinson's disease: recent advances'. Together they form a unique fingerprint.

Cite this